25080-84-6

Upstream product

• 54043-71-9 4-methoxy-2,2-dimethyl-4-oxobutanoic acid 
• 67-56-1 methanol 
• 1010-48-6 3-methyl-3-phenylbutanoic acid 
• 40474-22-4 cis/trans-2-Methyl-2-phenyl-1-cyclopropancarbonsaeure-methylester 
• 1041479-68-8 C₂₀H₂₆ClIn 
• 201230-82-2 carbon monoxide 
• 1041479-69-9 tris(2-methyl-2-phenylpropyl)indium 
• 1041479-67-7 2-methyl-2-phenylpropylindium(III) chloride 
• 74-88-4 methyl iodide 
• 600135-07-7 3-Methyl-3-{4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-phenyl}-butyronitrile 
• 17347-61-4 2,2-dimethylsuccinic anhydride 
• 71-43-2 benzene 
• 541-47-9 3-Methylbutenoic acid 

Downstream Products

• 5340-85-2 2,4-dimethyl-4-phenyl-2-pentanol 
• 26465-81-6 3,3-dimethylindan-1-one 
• 1010-48-6 3-methyl-3-phenylbutanoic acid 
• 67437-29-0 1,1,3-Triphenyl-3-methyl-1-butanol 
• 7403-42-1 4-Methyl-4-phenyl-2-pentanone 
• 120384-23-8 4-Methyl-4-phenyl-1-pentanale 
• 22156-64-5 4-methyl-4-phenylpentanenitrile 
• 21438-74-4 3-methyl-3-phenylbutan-1-ol 
• 1044851-46-8 methyl 2-azido-3-methyl-3-phenylbutanoate 
• 67437-24-5 1,1,3-Triphenyl-3-methyl-1-buten 

Relevant academic research and scientific papers

Metal-Free Enantioselective Oxidative Arylation of Alkenes: Hypervalent-Iodine-Promoted Oxidative C?C Bond Formation

The enantioselective oxyarylation of (E)-6-aryl-1-silyloxylhex-3-ene was achieved using a lactate-based chiral hypervalent iodine(III) reagent in the presence of boron trifluoride diethyl etherate. The silyl ether promotes the oxidative cyclization, and enhances the enantioselectivity. In addition, the corresponding aminoarylation was achieved.

Palladium-catalyzed oxidative carbonylation of alkyl and aryl indium reagents with CO under mild conditions

CO now can react with organoindium reagents. A novel palladium-catalyzed oxidative carbonylation reaction of organoindium reagents by CO gas with desyl chloride as oxidant was developed in supplementation with the classical methods for preparation of carboxylic acid derivatives. Primary, secondary alkyl indium reagents with β-hydrogens and aryl indium reagents were suitable substrates, and the reaction could be carried out at 60°C under 50 psi CO. Carbonylation of alkyl indium reagents can occur smoothly without additional base. Although the indium reagents were prepared from corresponding Grignard reagents (at low temperature), they displayed full compatibility with various functional groups under the protic reaction conditions. Preliminary mechanistic studies including stoichiometric and catalytic reaction examination provided evidence to support the operation of the mechanism consisted of oxidative addition of deslyl chloride to Pd(0) and quick tautomerization to give a palladium enolate species II (ROPdCl), displacement of the enolate group in II by R2OH, followed by CO insertion to give alkoxycarbonyl palladium complex V, which undergoes transmetalation with R13ln and reductive elimination to afford the product and a Pd(0) species. In this mechanism, the alkoxycarbonyl group was transferred to the palladium center prior to the alkyl group, different from traditional ways initiated from oxidative addition of alkyl halides to a Pd(0) species.

OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

Compounds that modulate PPAR activity and methods of preparation

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses methods for making the disclosed compounds.

Rate and Regioselectivity of Hydrogenolysis of Some Phenyl-Substituted Cyclopropanes

Several phenyl-substituted cyclopropane derivatives were investigated regarding rate and regiochemistry of their hydrogenolysis.The following reactivity sequence has been established: 1 2 4 7 9.Substituent effects are discussed and compared to those reported for monoactivated cyclopropanes.

Oxygen Rearrangement of Molecular Ions of 3-Phenylpropionates

The oxygen rearrangement in molecular ions of 3-phenylpropionates has been investigated with the aid of mass analyzed ion kinetic energy spectra.Elimination of an allyl radical followed by expulsion of ketene from the molecular ion of allyl 3-phenylpropionate is shown to result in formation of protonated benzaldehyde.The oxygen rearrangement has been found to be inoperative in ionized methyl 3-methyl-3-phenylbutyrate. + ions in the spectrum of the latter compound are formed by elimination of the 3-methyl substituent and subsequent methoxy migration.