251092-74-7

Upstream product

• 108-95-2 phenol 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 14063-82-2 4-chloro-2H-chromene-3-carboxaldehyde 
• 98-80-6 phenylboronic acid 
• 51870-64-5 4-phenyl-2H-benzo[b]pyran 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of 2-(4-phenyl-2h-chromen-3-yl)-1h-benzo[d]imidazole

A new series of 4-phenyl-2H-chromene-3-benzimidazoles (8a-o) were synthesized by the condensation of 4-phenyl-2H-chromene-3- carbaldehyde with o-phenylene diamines. The products were purified through column chromatography and structures of these compounds were characterized by IR, 1H & 13C NMR and mass spectral data. All the final compounds were screened for their antimicrobial activity and their efficacy were matched with ciprofloxacin. Five compounds (8b, 8d, 8i, 8l and 8o) were found to be most effective compounds of this series and with activities improved than ciprofloxacin under the tested conditions.

Design, Synthesis, and Antimicrobial Activity of (E)-4-Phenyl-2H-chromene-3-carbaldehyde O-[(1-Phenyl-1H-1,2,3-triazol-4-yl)methyl]oxime Derivatives

Abstract: A new series of 1,4-disubstituted 1,2,3-triazole derivatives tethered to a2H-chromene scaffold have beensynthesized via a click reaction. The synthesized chromene–triazole conjugateswere screened for their antibacterial activity against E. coli, S. aureus, P. aeruginosa and B.subtilis, as well as for antifungal activity against A. niger and C. albicans. Among the 17 synthesized compounds, 6 derivativesshowed the best antimicrobial activity. Molecular docking studies of the titlecompounds with carotenoid dehydrosqualene synthase (PDB: 2ZCS) revealed dockingscores within the range 98.241–91.488 against 106.573 for the reference ligandCiprofloxacin and with lanosterol 14α-demethylase (CYP51; PDB ID: 5V5Z),103.672–96.917 against 110.839 for the reference ligand Voriconazole.

CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS

The invention relates to compounds inhibiting phosphoinositide 3-kinases (PI3K), to pharmaceutical compositions comprising them and therapeutic use thereof in the treatment of disorders associated with PI3K enzymes.

N-phenylamide and N-pyridylamide derivatives, method of preparing them and pharmaceutical compositions containing them

The present invention relates to the compounds of formula (I) in which X, R1, R2 and R3are as defined in claim 1. These compounds are cholesteryl acyl transferase (ACAT) inhibitors.