251102-27-9

Usage

Uses

Used in Pharmaceutical Industry:
Pyrrolo[1,2-c]pyrimidine-3-carboxylic acid (9CI) is used as a therapeutic agent for its potential biological activities in the treatment of certain diseases. Its unique chemical structure and properties make it a promising candidate for the development of new drugs.
Used in Organic Synthesis:
Pyrrolo[1,2-c]pyrimidine-3-carboxylic acid (9CI) is used as a building block in organic synthesis, allowing for the creation of various chemical compounds with diverse applications.
Used in Medicinal Chemistry Research:
Pyrrolo[1,2-c]pyrimidine-3-carboxylic acid (9CI) is used as a research tool in medicinal chemistry to explore its potential as a therapeutic agent and to understand its interactions with biological targets. This knowledge can contribute to the design and development of new pharmaceuticals.

Upstream product

• 107407-80-7 ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate 
• 1003-29-8 2-pyrrole aldehyde 

Downstream Products

• 274-43-1 pyrrole<1,2-c>pyrimidine 
• 251102-28-0 3-(pyrrolo[1,2-c]pyrimidine)carboxaldehyde 

Relevant academic research and scientific papers

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

Pyrrolodiazines. 5. Synthesis, structure, and chemistry of pyrrolo[1,2- c]pyrimidine. Dipolar cycloaddition of pyrrolo[1,2-c]pyrimidinium ylides

An improved synthesis of pyrrolo[1,2-c]pyrimidines, including the parent system, was accomplished via sequential condensation of substituted pyrrole- 2-carboxaldehydes with tosylmethyl isocyanide (TOSMIC), followed by desulfonylation of the formed tosylpyrrolo[1,2-c]pyrimidines. Based on the ab initio calculations performed on the pyrrolo[1,2-c]pyrimidine 1a, some of the basic chemistry was investigated, including electrophilic substitution, addition of organolithium reagents, metalation with lithium diisopropylamide (LDA) and subsequent reaction with electrophiles, and formation of salts by quaternization of the nonbridgehead nitrogen. Azomethine ylides generated from pyrrolo[1,2-c]pyrimidinium salts undergo 1,3-dipolar cycloaddition with suitable dipolarophiles to give new dipyrrolo[1,2-a;1',2'-c]pyrimidine derivatives, with high regio- and stereoselectivity.

Improved synthesis of pyrrolo[1,2-c]pyrimidine and derivatives

An improved synthesis of pyrrolo[1,2-c]pyrimidine derivatives by cyclocondensation of pyrrole-2-carboxaldehydes with tosylmethyl isocyanide followed by desulfonylation of the resulting 2-tosylpyrrolo[1,2-c]- pyrimidines with sodium amalgam is described.