274-43-1Relevant academic research and scientific papers
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
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Paragraph 0450, (2018/03/09)
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
NEW CRTH2 ANTAGONISTS
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Page/Page column 131-132, (2013/03/26)
The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
New CRTh2 antagonists
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Paragraph 0674-0677, (2013/03/26)
The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
Derivatives of variolin b
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, (2008/06/13)
The invention provides antitumour compounds of formula (I), wherein R1 is an aromatic substituent; R2 is hydrogen or a substituent when the dotted line is absent, or R2 is absent when the dotted line represents a bond to give a double bond between the nitrogen which bears R2 and the carbon which bears R3; R3 is an oxo group ═O when the dotted line is absent or is a substituent when the dotted line represents a bond to give a double bond between the nitrogen bearing R2 and the carbon bearing R3; R4 is hydrogen or a substituent; and pharmaceutically acceptable salts thereof.
Pyrrolodiazines. 5. Synthesis, structure, and chemistry of pyrrolo[1,2- c]pyrimidine. Dipolar cycloaddition of pyrrolo[1,2-c]pyrimidinium ylides
Minguez, Jose M.,Vaquero, Juan J.,Alvarez-Builla, Julio,Castano, Obis,Andres, Jose L.
, p. 7788 - 7801 (2007/10/03)
An improved synthesis of pyrrolo[1,2-c]pyrimidines, including the parent system, was accomplished via sequential condensation of substituted pyrrole- 2-carboxaldehydes with tosylmethyl isocyanide (TOSMIC), followed by desulfonylation of the formed tosylpyrrolo[1,2-c]pyrimidines. Based on the ab initio calculations performed on the pyrrolo[1,2-c]pyrimidine 1a, some of the basic chemistry was investigated, including electrophilic substitution, addition of organolithium reagents, metalation with lithium diisopropylamide (LDA) and subsequent reaction with electrophiles, and formation of salts by quaternization of the nonbridgehead nitrogen. Azomethine ylides generated from pyrrolo[1,2-c]pyrimidinium salts undergo 1,3-dipolar cycloaddition with suitable dipolarophiles to give new dipyrrolo[1,2-a;1',2'-c]pyrimidine derivatives, with high regio- and stereoselectivity.
Improved synthesis of pyrrolo[1,2-c]pyrimidine and derivatives
Minguez, Jose M.,Vaquero, Juan J.,Garcia-Navio, Jose L.,Alvarez-Builla, Julio
, p. 4263 - 4266 (2007/10/03)
An improved synthesis of pyrrolo[1,2-c]pyrimidine derivatives by cyclocondensation of pyrrole-2-carboxaldehydes with tosylmethyl isocyanide followed by desulfonylation of the resulting 2-tosylpyrrolo[1,2-c]- pyrimidines with sodium amalgam is described.
