251107-17-2Relevant academic research and scientific papers
Piperidine-based heterocyclic oxalyl amides as potent p38α MAP kinase inhibitors
Mavunkel, Babu J.,Perumattam, John J.,Tan, Xuefei,Luedtke, Gregory R.,Lu, Qing,Lim, Don,Kizer, Darin,Dugar, Sundeep,Chakravarty, Sarvajit,Xu, Yong-jin,Jung, Joon,Liclican, Albert,Levy, Daniel E.,Tabora, Jocelyn
scheme or table, p. 1059 - 1062 (2010/06/14)
The design and synthesis of a new class of p38α MAP kinase inhibitors based on 4-fluorobenzylpiperidine heterocyclic oxalyl amides are described. Many of these compounds showed low-nanomolar activities in p38α enzymatic and cell-based cytokine TNFα produc
Indole-type derivatives as inhibitors of p38 kinase
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Page/Page column 11, (2008/06/13)
The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.
