25113-27-3Relevant academic research and scientific papers
Rapid assessment of protecting-group stability by using a robustness screen
Collins, Karl D.,Ruehling, Andreas,Lied, Fabian,Glorius, Frank
supporting information, p. 3800 - 3805 (2014/04/03)
An experimentally simple method has been developed to rapidly establish the stability of widely utilized silyl, acetal, and carbamate protecting groups to a given set of reaction conditions. Assessment of up to twelve protecting groups in a single experiment has been demonstrated. Evaluation of this protocol in two unrelated synthetic transformations suggests that this method can be used to select appropriate protecting groups in the design of synthetic routes.
PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES
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Paragraph 0091, (2013/08/15)
A method of synthesizing Pyrazoles by means of the oxidative conversion of Enamines with suitable N-containing carboxylic acid derivatives in the presence of copper ions and 2-picolinic acid derivatives is provided.
PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES
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Paragraph 0170, (2013/03/26)
The invention describes a novel process for synthesizing pyrazoles by means of oxidative conversion of enamines with suitable N-containing carboxylic acid derivatives.
An efficient copper-catalyzed formation of highly substituted pyrazoles using molecular oxygen as the oxidant
Suri, Mamta,Jousseaume, Thierry,Neumann, Julia J.,Glorius, Frank
supporting information; experimental part, p. 2193 - 2196 (2012/09/21)
An efficient Cu-catalyzed formation of tetra-substituted pyrazoles is reported. In this atom economic process, readily available enamines and nitriles are reacted by C-C and N-N bond formation. Oxygen has been successfully used as the oxidant, which has i
Efficient synthesis of pyrazoles: Oxidative C-C/N-N bond-formation cascade
Neumann, Julia J.,Suri, Mamta,Glorius, Frank
supporting information; experimental part, p. 7790 - 7794 (2011/01/09)
Golden section: A novel synthetic strategy for the synthesis of tetrasubstituted pyrazoles is provided. In an efficient C-C/N-N bond-formation cascade, enamines and nitriles are oxidatively coupled to deliver pyrazoles in good yields (see scheme). The rea
1,3-Dipolar Cycloadditions, 89. New Contributions to the Chemistry of Diphenylnitrilimine
Clovis, James S.,Fliege, Werner,Huisgen, Rolf
, p. 3062 - 3070 (2007/10/02)
Methyl propiolate, tetrolate, and phenylpropiolate combine with diphenylnitrilimine (1) to afford regioisomeric cycloadducts; the preferential orientation shifts in the sequence given from the pyrazole-5-carboxylic ester to the 4-carboxylic ester.Correspo
