25119-60-2

Basic information

• Product Name: N-benzyl-2-(5-methoxy-1H-indol-3-yl)ethan-1-amine
• Synonyms: N-benzyl-2-(5-methoxy-1H-indol-3-yl)ethan-1-amine
• CAS NO: 25119-60-2
• Molecular Weight: 280.37
• Mol File: 25119-60-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-benzyl-2-(5-methoxy-1H-indol-3-yl)ethan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(5-methoxy-1H-indol-3-yl)ethan-1-amine(25119-60-2)
• EPA Substance Registry System: N-benzyl-2-(5-methoxy-1H-indol-3-yl)ethan-1-amine(25119-60-2)

Safety Data

• Hazardous Substances Data: 25119-60-2(Hazardous Substances Data)

Upstream product

• 61675-19-2 5-methoxy-3-(2-nitroethylenyl)-1H-indole 
• 1006-94-6 5-methoxylindole 
• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 100-52-7 benzaldehyde 
• 37465-51-3 benzylidene-[2-(5-methoxy-indol-3-yl)-ethyl]-amine 

Downstream Products

• 1366416-31-0 N-allyl-N-benzyl-(5-methoxy)tryptamine 
• 86293-40-5 10-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one 
• 86293-41-6 10-hydroxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one 

Relevant articles and documents

Design and synthesis of C10 modified and ring-truncated canthin-6-one analogues as effective membrane-active antibacterial agents

A series of canthin-6-one analogues were designed and synthesized in order to study their antibacterial activity and structure–activity relationships. Compound 22 showed a broad spectrum of antibacterial activity and exhibited better bactericidal effect (

Synthesis and evaluation of ester derivatives of 10-hydroxycanthin-6-one as potential antimicrobial agents

As part of our continuing research on canthin-6-one antimicrobial agents, a new series of ester derivatives of 10-hydroxycanthin-6-one were synthesized using a simple and effective synthetic route. The structure of each compound was characterized by NMR, ESI-MS, FT-IR, UV, and elemental analysis. The antimicrobial activity of these compounds against three phytopathogenic fungi (Alternaria solani, Fusarium graminearum, and Fusarium solani) and four bacteria (Bacillus cereus, Bacillus subtilis, Ralstonia solanacearum, and Pseudomonas syringae) were evaluated using the mycelium linear growth rate method and micro-broth dilution method, respectively. The structure-activity relationship is discussed. Of the tested compounds, 4 and 7s displayed significant antifungal activity against F. graminearum, with inhibition rates of 100% at a concentration of 50 μg/mL. Compounds 5, 7s, and 7t showed the best inhibitory activity against all the tested bacteria, with minimum inhibitory concentrations (MICs) between 3.91 and 31.25 μg/mL. Thus, 7s emerged as a promising lead compound for the development of novel canthine-6-one antimicrobial agents.

Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: A metal-catalyzed variation on the Pictet-Spengler theme

An efficient and broadly applicable alternative to the classical Pictet-Spengler synthesis of tetrahydro-β-carbolines is presented. The method relies on metal-catalyzed isomerization of allylic amines to form reactive iminium intermediates which can be trapped by a tethered indole nucleophile. The Royal Society of Chemistry 2012.