2512-27-8

Basic information

• Product Name: N,4-diphenylpiperazine-1-carbothioamide
• Synonyms: 1-piperazinecarbothioamide, N,4-diphenyl-; N,4-Diphenylpiperazine-1-carbothioamide
• CAS NO: 2512-27-8
• Molecular Formula: C₁₇H₁₉N₃S
• Molecular Weight: 297.4179
• Mol File: 2512-27-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 445.5°C at 760 mmHg
• Flash Point: 223.2°C
• Density: 1.243g/cm³
• Vapor Pressure: 3.94E-08mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: N,4-diphenylpiperazine-1-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,4-diphenylpiperazine-1-carbothioamide(2512-27-8)
• EPA Substance Registry System: N,4-diphenylpiperazine-1-carbothioamide(2512-27-8)

Safety Data

• Hazardous Substances Data: 2512-27-8(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 92-54-6 4-phenyl-1-piperazine 

Downstream Products

• 1421761-31-0 C₃₄H₃₆N₆S 
• 232262-80-5 2-(4-phenylpiperazine-1-yl)benzo[d]thiazole 
• 1157584-34-3 [Ru(η6-cym)(PPh3)(κ2N,S-PhNC(S)NC4H8NPh)]BPh4 

Relevant articles and documents

Synthesis and evaluation of unsymmetrical heterocyclic thioureas as potent β-glucuronidase inhibitors

Thiourea analogs 1-20 were synthesized and evaluated for their in vitro β-glucuronidase inhibitory potential. The compounds 9 (0.86 ± 0.01 μM), 6 (1.24 ± 0.01 μM), 16 (1.64 ± 0.02 μM) and 15 (2.12 ± 0.02 μM) showed potent activity. Other analogs 1-5, 7, 8

A ligand free copper(II) catalyst is as effective as a ligand assisted Pd(II) catalyst towards intramolecular C-S bond formation via C-H functionalization

Copper(I) catalysts are usually ineffective on the other hand Pd(II) catalysts are quite effective in promoting intramolecular sp2 C-H functionalization (C-S bond formation). Herein, we have developed a ligand assisted Pd(II) catalyzed C-S bond formation via C-H activation from arylthioureas leading to the formation of 2-aminobenzothiazoles for substrates bearing electron donating (EDG) groups in the aryl ring. However without the assistance of ligand this Pd(II) catalyzed reaction is quite unproductive particularly for thioureas possessing strongly electron donating groups in the aryl rings. Interestingly, the ligand free Cu(II) catalyzed oxidative cyclization of arylthioureas are equally effective both for arylthioureas possessing electron donating as well as electron withdrawing groups in the aryl rings.

Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions

Three series of N-acyl and N-cyclohexyl- or N-methyl or N-phenyl-thioureas of 4-substituted (methyl, phenyl, 2-pyridyl)piperazines (4-12) were synthesised according to a highly convergent one-pot procedure and tested in vivo (local anaesthetic, anti-hyper