2513-23-7Relevant academic research and scientific papers
HKOH-1: A Highly Sensitive and Selective Fluorescent Probe for Detecting Endogenous Hydroxyl Radicals in Living Cells
Bai, Xiaoyu,Huang, Yueyang,Lu, Mingyang,Yang, Dan
supporting information, p. 12873 - 12877 (2017/09/25)
The hydroxyl radical (.OH), one of the most reactive and deleterious reactive oxygen species (ROS), has been suggested to play an essential role in many physiological and pathological scenarios. However, a reliable and robust method to detect e
DIARYLETHER-BASED FLUOROGENIC PROBES FOR DETECTION OF HYPOCHLOROUS ACID OR HYDROXYL RADICAL
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Paragraph 0097, (2016/11/14)
Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening hypochlorous acid or hydroxyl radical. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining hypochlorous acid or hydroxyl radical in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of hypochlorous acid or hydroxyl radical in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening hypochlorous acid or hydroxyl radical or compounds that can increase or decrease the level of hypochlorous acid or hydroxyl radical in chemical and biological samples.
Construction of long-wavelength fluorescein analogues and their application as fluorescent probes
Xiong, Xiaoqing,Song, Fengling,Chen, Gengwen,Sun, Wen,Wang, Jingyun,Gao, Pan,Zhang, Yukang,Qiao, Bo,Li, Wenfang,Sun, Shiguo,Fan, Jiangli,Peng, Xiaojun
supporting information, p. 6538 - 6545 (2013/07/05)
Born to dye: Five fluorescein analogues were synthesised (see scheme). One analogue was found to emit in the NIR region with a high quantum yield, excellent photostability and good permeability. Three derivatives were found to specifically stain mitochondria and one dye responds to thiols with a strong turn-on NIR fluorescence signal and colorimetric change, in vitro and in vivo. Copyright
Sensors, and methods of making and using the same
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, (2008/12/06)
The present invention is directed, in part, to sensors for detecting metal ions, and methods of making and using the same.
ZP4, an improved neuronal Zn2+ sensor of the Zinpyr family
Burdette, Shawn C.,Frederickson, Christopher J.,Bu, Weiming,Lippard, Stephen J.
, p. 1778 - 1787 (2007/10/03)
A second-generation fluorescent sensor for Zn2+ from the Zinpyr family, ZP4, has been synthesized and characterized, ZP4 (Zinpyr-4, 9-(o-carboxyphenyl)-2-chloro-5-[2-{bis(2-pyridylmethyl)-aminomethyl}- N-methylaniline]-6-hydroxy-3-xanthanone) is prepared via a convergent synthetic strategy developed from previous studies with these compounds, ZP4, like its predecessors, has excitation and emission wavelengths in the visible range (～500 nm), a dissociation constant (Kd) for Zn2+ of less than 1 nM and a high quantum yields (Π = ～0.4), making it well suited for biological applications, A 5-fold fluorescent enhancement is observed under simulated physiological conditions corresponding to the binding of the Zn2+ cation to the sensor, which inhibits a photoinduced electron transfer (PET) quenching pathway. The metal-binding stereochemistry of ZP4 was evaluated through the synthesis and X-ray structural characterization of [M(BPAMP)(H2O)n]+ complexes, where BPAMP is [2-{bis(2-pyridylmethyl)aminomethyl}-N-methylaniline]-phenol and M = Mn2+, Zn2+ (n = 1) or Cu2+ (n = 0).
Fluorescein-based metal sensors, and methods of making and using the same
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, (2008/06/13)
The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same.
