18362-80-6

Upstream product

• 4091-99-0 2-(3,6-diacetyloxy-2,7-dichloro-9H-xanthen-9-yl)benzoic acid 
• 827020-41-7 bis(2,4-dinitrobenzenesulfonyl)-2',7'-dichlorofluorescein 
• 106070-31-9 2-(2,7-dichloro-3,6-dihydroxy-9H-xanthen-9-yl)benzoic acid 
• 76-54-0 2',7'-dichlorofluorescein 
• 85-44-9 phthalic anhydride 
• 95-88-5 4-Chlororesorcinol 
• 1181325-08-5 6-(but-3-en-1-yloxy)-2,7-dichloro-9-(2-(hydroxymethyl)phenyl)-3Hxanthen-3-one 
• 2513-23-7 2'-Carboxy-5-chloro-2,4-dihydroxybenzophenone 
• 2044-85-1 2',7'-dichlorodihydrofluorescein diacetate 

Downstream Products

• 121408-61-5 2-(2,7-Dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid (2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester 
• 914203-46-6 9-(o-carboxyphenyl)-2,7-dichloro-4,5-bis[bis(2-pyridylmethyl)-aminomethyl]-6-hydroxy-3-xanthanone 
• 719297-59-3 allyl 2-(6-(allyloxy)-2,7-dichloro-3-oxo-3H-xanthen-9-yl)benzoate 
• 889663-68-7 C₃₂H₂₂Cl₂O₇ 
• 889663-66-5 C₃₃H₂₄Cl₂O₇ 
• 889663-71-2 C₃₃H₂₁Cl₂F₃O₆ 
• 1309362-32-0 2-[2,7-dichloro-3-oxo-6-(prop-2-ynyloxy)-3H-xanthen-9-yl]benzoic acid prop-2-ynyl ester 
• 1300008-85-8 2,7-dichloro-9,12-di-iodofluorescein 

Relevant academic research and scientific papers

Influence of vehicles on antioxidant efficacy in hair

The UV radiation of sunlight is known to damage human hair, causing fibre degradation. Gallic acid (GA) was used as an active principle because of its antioxidant properties, which confer protection against free radicals. Encapsulation technologies, such

HKOH-1: A Highly Sensitive and Selective Fluorescent Probe for Detecting Endogenous Hydroxyl Radicals in Living Cells

The hydroxyl radical (.OH), one of the most reactive and deleterious reactive oxygen species (ROS), has been suggested to play an essential role in many physiological and pathological scenarios. However, a reliable and robust method to detect e

Fluorescent probes for hydrogen peroxide based on a non-oxidative mechanism

Highly selective detection of H2O2 through a non-oxidative mechanism has been achieved by desulfonylation of 1 to the corresponding fluorescein, This approach has been used for the intracellular formation of H2O2/sub

Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B

The National Cancer Institute (NCI) Diversity Set was screened for potential inhibitors of phospho-MurNAc-pentapeptide translocase MraY from Escherichia coli using a primary fluorescence enhancement assay, followed by a secondary radiochemical assay. One new MraY inhibitor was identified from this screen, a naphthylisoquinoline alkaloid michellamine B, which inhibited E. coli MraY (IC50 456 μM) and Bacillus subtilis MraY (IC50 386 μM), and which showed antimicrobial activity against B. subtilis (MIC 16 μg/mL). Following an earlier report of halogenated fluoresceins identified from a combined MraY/MurG screen, three halogenated fluoresceins were tested as inhibitors of E. coli MraY and E. coli MurG, and phloxine B was identified as an inhibitor of E. coli MraY (IC50 32 μM). Molecular docking of inhibitor structures against the structure of Aquifex aeolicus MraY indicates that phloxine B appears to bind to the Mg2+ cofactor in the enzyme active site, while michellamine B binds to a hydrophobic groove formed between transmembrane helices 5 and 9.

FLUOROMETER FOR FLOW INJECTION ANALYSIS WITH APPLICATION TO OXIDASE ENZYME DEPENDENT REACTIONS.

A simple effective flow fluorometer has been assembled and operated in conjunction with a flow injection analysis (FIA) system. A submicroliter capillary sheath flow cell is used for fluorescence detection with a laser source. The instrument has been test

Water-Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome-Targeted Cancer Photodynamic Therapy

Helicene-based therapeutic agents for organelle-targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water-soluble nanoparticles containing twisted double [7]carbohelicene (D7H-NPs) are prepared

Novel ratiometric fluorescent probe based on internal reference and its detection of hydrazine

In this work, dual-emissive ratiometric fluorescent system was constructed by the introduction of an ideal internal reference. By virtue of its unique alkalinity, N2H4 could undergo a hydrazinolysis reaction with the ester group of F1, inducing remarkable fluorescence enhancement while the blue fluorescence of the internal reference DPA remained constant. Consequently, the fluorescence intensity ratios (I540/I440) were proportional to the concentrations of N2H4, which was beneficial for the exactly quantitative detection. The skillful strategy granted the sensing system advantages such as relative good solubility in aqueous media, easy-to-design, simple synthesis, large emission shift, good ratiometric response, as well as the successful application in real water samples and cell imaging.

Fat mass and obesity-associated protein (FTO) inhibitors prepared from 9-(2-carboxyphenyl) xanthene compounds and therapeutic effects thereof

The invention relates to usage of the following general formula I as a drug for diseases targeting fat mass and obesity-associated protein (FTO), and provides usage of 9-(2-carboxyphenyl) xanthene compounds in preparation of FTO inhibitors. Specifically, the invention discloses usage of the 9-(2-carboxyphenyl) xanthene compounds as shown in the formula (I), as well as derivatives and pharmaceutically acceptable salts thereof, in preparation of the FTO inhibitors or pharmaceutical compositions for treating FTO-related diseases.

Coordination-Accelerated Radical Formation from Acyclic Enediynes for Tumor Cell Suppression

A maleimide-based acyclic enediyne with salicylaldiminato substituents at the alkyne termini was synthesized, which was further chelated with three kinds of metal-ions, CuII, ZnII, and MgII, and form metalloenediynes. The cycloaromatization of this thermally inactive enediyne ligand was greatly accelerated through the coordination with metal ions. Specifically, the CuII-metalloenediyne showed an extremely low onset temperature of 55 °C and underwent spontaneous cycloaromatization at ambient temperature to produce free radicals, followed by generation of reactive oxygen species in the physiological environment. The metalloenediyne exhibited excellent DNA cleavage ability and high cytotoxicity towards HeLa cells, with half-maximal inhibitory concentration values comparable to many commercial antitumor agents. The combination of the electron-withdrawing effect of the maleimide moiety at the ene position and metal coordination at the yne termini provides a new inspiration for designing and synthesizing highly efficient enediyne antitumor agents.

Detection hydrazine florescent probe of fluorescein matrix structure

The invention provides a detection hydrazine florescent probe of a fluorescein matrix structure and relates to the field of fluorescent probes. The detection hydrazine florescent probe is prepared bythe following steps: S1, adding proper amounts of dichlorofluorescein and triethylamine into a round-bottom flask; S2, adding a proper amount of anhydrous dichloroethane, performing mixing and stirring, slowly adding dropwise a proper amount of an anhydrous dichloroethane solution into which acryloyl chloride is dissolved into the round-bottom flask, performing a reaction at the room temperature,and performing TLC (thin-layer chromatography) monitoring; and S3, after the reaction is completed, relieving the vacuum state, performing spinning drying on a solvent, and performing column chromatography, so as to obtain the probe. Through a reaction of hydrazine with a probe molecule substrate by virtue of an intensive nucleophilic property of the hydrazine, a dichloro fluorophore matrix is released, the fluorescence develops from zero, and furthermore, detection research on hydrazine can be achieved.