25130-85-2Relevant academic research and scientific papers
A new square planar mononuclear MnIII complex for catalytic epoxidation of stilbene
Tran, Lien-Hoa,Eriksson, Lars,Sun, Licheng,?kermark, Bj?rn
, p. 1150 - 1153 (2008)
The manganese(III) complex (2) with a diamide ligand has been synthesized. This complex was found to catalyze both the epoxidation of (Z)- and (E)-stilbene with high conversion and the oxidation of benzyl alcohol to benzaldehyde.
A new iron(III)-salen catalyst for enantioselective Conia-ene carbocyclization
Shaw, Subrata,White, James. D.
, p. 13578 - 13581 (2014)
A chiral iron(III)-salen complex based on a cis-2,5-diaminobicyclo[2.2.2]octane scaffold catalyzes asymmetric Conia-ene-type cyclization of α-functionalized ketones containing an unactivated terminal alkyne and produces an exo-methylenecycloalkane possess
Asymmetric Catalysis with Iron-Salen Complexes
Shaw, Subrata,White, James D.
, p. 2768 - 2780 (2016/08/31)
Iron(III)-salen complexes based on a chiral cis-2,5-diaminobicyclo[2.2.2]octane scaffold are used as catalysts for a variety of stereo selective reactions. High enantio- and diastereoselectivities can be achieved with these catalysts in sulfa-Michael conjugate addition to acyclic α,β-unsaturated ketones, in regioselective δ-addition of thiols to acyclic α,β,γ,δ-unsaturated ketones, and in Conia-ene carbocyclization of alkynyl-substituted β-dicarbonyl compounds. The use of these chiral iron-salen complexes as catalysts provides a new method for conducting these three important reactions under environmentally sustainable conditions.
Fine tuning of the oxidation locus, and electron transfer, in nickel complexes of pro-radical ligands
Rotthaus, Olaf,Jarjayes, Olivier,Thomas, Fabrice,Philouze, Christian,Valle, Carlos Perez Del,Saint-Aman, Eric,Pierre, Jean-Louis
, p. 2293 - 2302 (2008/02/03)
A large number of complexes of the first-row transition metals with non-innocent ligands has been characterized in the last few years. The localization of the oxidation site in such complexes can lead to discrepancies when electrons can be removed either
Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria
Macielag, Mark J.,Demers, James P.,Fraga-Spano, Stephanie A.,Hlasta, Dennis J.,Johnson, Sigmond G.,Kanojia, Ramesh M.,Russell, Ronald K.,Sui, Zhihua,Weidner-Wells, Michele A.,Werblood, Harvey,Foleno, Barbara D.,Goldschmidt, Raul M.,Loeloff, Michael J.,Webb, Glenda C.,Barrett, John F.
, p. 2939 - 2945 (2007/10/03)
A new class of inhibitors of the two-component regulatory systems (TCS) of bacteria was discovered based on the salicylanilide screening hits, closantel (1) and tetrachlorosalicylanilide (9). A systematic SAR study versus a model TCS, KinA/Spo0F, demonstrated the importance of electron- attracting substituents in the salicyloyl ring and hydrophobic groups in the anilide moiety for optimal activity. In addition, derivatives 8 and 16, containing the 2,3-dihydroxybenzanilide structural motif, were potent inhibitors of the autophosphorylation of the KinA kinase, with IC50s of 2.8 and 6.3 μM, respectively. Compound 8 also inhibited the TCS mediating vancomycin resistance (VanS/VanR) in a genetically engineered Enterococcus faecalis cell line at concentrations subinhibitory for growth. Closantel (1), tetrachlorosalicylanilide (9), and several related derivatives (2, 7, 10, 11, 20) had antibacterial activity against the drug-resistant organisms, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).
