251300-28-4

Basic information

• Product Name: 5-BROMO-3-FLUOROSALICYLALDEHYDE
• Synonyms: 5-BROMO-3-FLUOROSALICYLALDEHYDE;5-BROMO-3-FLUORO-2-HYDROXYBENZALDEHYDE;5-BROMO-3-FLUORO-2-HYDROXYBENZENECARBALDEHYDE;5-Bromo-3-fluoro-2-hydroxybenzaldehyde 97%;5-Bromo-3-fluorosalicylaldehyde, 4-Bromo-2-fluoro-6-formylphenol;5-BroMo-3-fluorosalicylaldehyde;5-Bromo-3-fluoro-2-hydroxybenzaldehyde97%
• CAS NO: 251300-28-4
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• EINECS: 1533716-785-6
• Product Categories: Aldehydes;C7;Carbonyl Compounds;Aryl Fluorinated Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 251300-28-4.mol

Chemical Properties

• Melting Point: 112-116 °C(lit.)
• Boiling Point: 226.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.826±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.36±0.23(Predicted)
• CAS DataBase Reference: 5-BROMO-3-FLUOROSALICYLALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-FLUOROSALICYLALDEHYDE(251300-28-4)
• EPA Substance Registry System: 5-BROMO-3-FLUOROSALICYLALDEHYDE(251300-28-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 251300-28-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research and Development:
5-Bromo-3-Fluorosalicylaldehyde is used as a chemical intermediate and reagent for various research and development purposes. Its unique structure with both bromine and fluorine elements makes it a valuable compound for creating new chemical entities and studying their properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromo-3-Fluorosalicylaldehyde is used as a building block for the synthesis of various drug molecules. Its aromatic nature and the presence of bromine and fluorine atoms can contribute to the development of new therapeutic agents with improved pharmacological properties.
Used in Material Science:
5-Bromo-3-Fluorosalicylaldehyde is used as a precursor in the synthesis of advanced materials, such as polymers and coatings, that exhibit unique properties due to the presence of bromine and fluorine atoms. These materials can be utilized in various applications, including electronics, aerospace, and automotive industries.
Used in Analytical Chemistry:
5-Bromo-3-Fluorosalicylaldehyde is used as a reagent in analytical chemistry for the detection and quantification of various compounds. Its reactivity with specific analytes can be exploited to develop sensitive and selective analytical methods for environmental, clinical, or industrial applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Bromo-3-Fluorosalicylaldehyde is used as a starting material for the synthesis of novel pesticides and herbicides. The introduction of bromine and fluorine atoms can enhance the biological activity and selectivity of these agrochemicals, leading to more effective and environmentally friendly products.

Upstream product

• 2105-94-4 4-bromo-2-fluorophenol 
• 100-97-0 hexamethylenetetramine 
• 394-50-3 3-fluorosalicylaldehyde 

Downstream Products

• 470668-70-3 5-bromo-3-fluoro-2-methoxybenzaldehyde 
• 876918-40-0 5-bromo-3-fluoro-2-hydroxybenzonitrile 
• 251300-29-5 5-bromo-3-fluoro-2-hydroxybenzoic acid 

Relevant articles and documents

An improved method for the synthesis of 3-fluorosalicylic acid with application to the synthesis of 3-(Trifluoromethyl)salicylic acid

An improved method for the synthesis of 3-fluorosalicylic acid is described. A positional protective group strategy allows formylation selectively at the ortho position of 4-bromo-2-fluorophenol. Oxidation of the resulting salicylaldehyde to the salicylic acid, followed by debromination, affords 3-fluorosalicylic acid. The method has also been applied to the synthesis of 3-(trifluoromethyl)salicylic acid.

HETEROCYCLIC COMPOUND, APPLICATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Disclosed in the present invention are a heterocyclic compound, an application thereof and a pharmaceutical composition comprising the same. Provided by the present invention are a heterocyclic compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has a novel structure and a good inhibitory activity against autotaxin (ATX).

SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING

A compound of formula (I), wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted pyrazolo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrazolo[1,5-a]pyrimidinyl carboxamide compounds described herein include 2-heterocyclyl-4-alkyl-pyrazolo[1,5-a]pyrirnidine-3-carboxarnide compounds and variants thereof.

As the NS4B inhibitor benzofuran analogs (by machine translation)

The present invention discloses a kind of as NS4B benzofuran analogue inhibitors, in particular to the formula (I) below or a pharmaceutically acceptable salt thereof. (by machine translation)

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

TRICYCLIC COMPOUNDS AS INHIBITORS FOR THE PRODUCTION OF BETA-AMYLOID

Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: formula (I), wherein X is selected from the group of CH2, O, and NR2; m = 0 or 1; R1 at each instance is selected from th

METHOD FOR PRODUCING DIBROMOFLUOROBENZENE DERIVATIVE

Methods of the present invention for producing dibromofluorobenzene derivatives (compounds II) comprise Step 1, in which compounds (I) having the following general formula (I): epImage id=""ia01"" he=""33"" wi=""128"" file=""imga0001.tif"" img-content=""