251308-36-8Relevant articles and documents
The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1
Cody, Wayne L.,Cai, Cuiman,Doherty, Annette M.,Edmunds, Jeremy J.,He, John X.,Narasimhan, Lakshmi S.,Plummer, Janet S.,Rapundalo, Stephen T.,Rubin, J. Ronald,Van Huis, Chad A.,Yves, St-Denis,Winocour, Peter D.,Siddiqui, M. Arshad
, p. 2497 - 2502 (1999)
Utilizing X-ray crystallography and molecular modeling, highly potent and selective peptidomimetic thrombin inhibitors have been designed containing a rigid piperazinedione template. The synthesis and biological activity of these compounds will be described.