25131-98-0

Usage

Uses

Used in Pharmaceutical Industry:
3-[p-(hexyloxy)phenyl]propionic acid is used as a pain reliever for conditions such as headaches, muscle aches, and minor injuries. It is effective in alleviating discomfort and promoting a sense of well-being.
3-[p-(hexyloxy)phenyl]propionic acid is used as a fever reducer to lower elevated body temperatures caused by infections or other illnesses, helping to prevent complications associated with high fevers.
3-[p-(hexyloxy)phenyl]propionic acid is used as an anti-inflammatory medication to treat conditions characterized by inflammation, such as arthritis and menstrual cramps. It helps to reduce swelling, redness, and discomfort associated with these conditions.
It is important to use 3-[p-(hexyloxy)phenyl]propionic acid according to the recommended dosage and directions to avoid potential side effects or complications. This medication is commonly available over-the-counter, making it accessible for a wide range of users seeking relief from various ailments.

InChI:InChI=1/C15H22O3/c1-2-3-4-5-12-18-14-9-6-13(7-10-14)8-11-15(16)17/h6-7,9-10H,2-5,8,11-12H2,1H3,(H,16,17)

Upstream product

• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 111-25-1 1-bromo-hexane 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 208538-32-3 C₁₆H₂₄O₃ 

Downstream Products

• 25131-99-1 3-(4-Hexyloxy-phenyl)-propionamide 
• 351014-51-2 vinyl 3-(4-n-hexyloxyphenyl)propanoate 

Relevant academic research and scientific papers

Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes

The development of selective inhibitors for individual PLA2 enzymes is necessary in order to target PLA2-specific signaling pathways, but it is challenging due to the observed promiscuity of known PLA2 inhibitors. In the current work, we present the development and application of a variety of synthetic routes to produce pentafluoro, tetrafluoro, and trifluoro derivatives of activated carbonyl groups in order to screen for selective inhibitors and characterize the chemical properties that can lead to selective inhibition. Our results demonstrate that the pentafluoroethyl ketone functionality favors selective inhibition of the GVIA iPLA2, a very important enzyme for which specific, potent, reversible inhibitors are needed. We find that 1,1,1,2,2-pentafluoro-7-phenyl-heptan-3-one (FKGK11) is a selective inhibitor of GVIA iPLA2 (XI(50) = 0.0073). Furthermore, we conclude that the introduction of an additional fluorine atom at the α′ position of a trifluoromethyl ketone constitutes an important strategy for the development of new potent GVIA iPLA2 inhibitors.

The effect of vinyl esters on the enantioselectivity of the lipase-catalysed transesterification of alcohols

The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol 1 was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alcohol was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, respectively. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalysed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of 1 was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-1 and then the enantioselective hydrolysis of the resultant ester to afford (S)-1.

THE SYNTHESIS OF ARYLPROPIONIC ACIDS AND THE QUANTITATIVE RELATIONSHIP BETWEEN THE STRUCTURE AND THE ACTIVATION OF FIBRINOLYSIS

A number of substituted 2-arylpropionic (IV) and 3-arylpropionic (V) acids were prepared and their activity in the activation of fibrinolysis and the inhibition of heat denaturation of serum albumin was evaluated.The results were worked up using the method of regression analysis.From the regression equation obtained it may be considered that both activities are affected mainly by the lipophilicity of the aromatic substituents.The effect of branching in the connecting chain between the carboxyl group and the aromatic ring is negligible in both activities.Thelinear dependence of the fibrinolytic capacity on lipophilicity is in both series of acids, IV and V, characterized by a distinct decrease in activity, following the attainment of the optimum value of lipophilicity.In the series of cinnamic acids (VI) regression equations concerning the inhibition of the denaturation of serum albumin and the activation of fibrinolysis were also calculated, showing a linear dependence of these activities on the lipophilicity of the varying substituents R and X.Summary regression equations were derived for both activities in the whole set of acids I-VI.Both the inhibition of the denaturation of serum albumin , and the activation of fibrinolysis depends on the lipophilicity of the mentioned acids exclusively.The modification of the connecting chain between the carboxyl group and the aromatic ring affects both activities primarily by the corresponding change in lipophilicity.