251325-31-2Relevant academic research and scientific papers
Development of a supply route for the synthesis of an iNOS inhibitor: Complications of the key SN2 reaction
Rassias, Geracimos,Hermitage, Stephen A.,Sanganee, Mahesh J.,Kincey, Peter M.,Smith, Neil M.,Andrews, Ian P.,Borrett, Gary T.,Slater, Graham R.
body text, p. 774 - 780 (2010/04/22)
The original medicinal chemistry synthesis of an iNOS inhibitor presented several challenges that had to be overcome in order to constitute a supply route suitable for operation on a multikilo scale. The key step in the synthesis is an SN2 reac
(2R, 5R)-6N-(1-IMINOETHYL)-2,6-DIAMINO-5-METHYL-4-THIOHEXANOIC ACID; SALTS THEREOF; A PROCESS FOR THEIR PREPARATION; PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDECINE
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Page/Page column 9; 10, (2010/02/10)
ABSTRACT A process for making a medicinal vial in which a vial and a closure are moulded in parallel in respective vial and closure moulds, then the closure and vial are automatically assembled together, all in a sterile environment. An apparatus for perf
