251349-54-9

Basic information

• Product Name: 2-[(2S)-1-[(1,1-diMethylethoxy)carbonyl]2-pyrrolidinyl]-4-thiazolecarboxylic acid
• Synonyms: 2-[(2S)-1-[(1,1-diMethylethoxy)carbonyl]2-pyrrolidinyl]-4-thiazolecarboxylic acid;Antibiotic-5d;2-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid
• CAS NO: 251349-54-9
• Molecular Formula: C₁₃H₁₈N₂O₄S
• Molecular Weight: 298.35802
• Mol File: 251349-54-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 459.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• PKA: 3.73±0.10(Predicted)
• CAS DataBase Reference: 2-[(2S)-1-[(1,1-diMethylethoxy)carbonyl]2-pyrrolidinyl]-4-thiazolecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2S)-1-[(1,1-diMethylethoxy)carbonyl]2-pyrrolidinyl]-4-thiazolecarboxylic acid(251349-54-9)
• EPA Substance Registry System: 2-[(2S)-1-[(1,1-diMethylethoxy)carbonyl]2-pyrrolidinyl]-4-thiazolecarboxylic acid(251349-54-9)

Safety Data

• Hazardous Substances Data: 251349-54-9(Hazardous Substances Data)

Usage

General Description

2-[(2S)-1-[(1,1-dimethylethoxy)carbonyl]2-pyrrolidinyl]-4-thiazolecarboxylic acid is a chemical compound with a molecular formula C15H21N3O4S. It is an inhibitor of cancer growth and a potent inhibitor of Cdc7, a serine/threonine protein kinase that regulates cell division. 2-[(2S)-1-[(1,1-diMethylethoxy)carbonyl]2-pyrrolidinyl]-4-thiazolecarboxylic acid shows potential for use in cancer therapy due to its ability to prevent the progression of cancer cells. Its structure contains a pyrrolidine ring, a thiazole ring, and a carboxylic acid functional group, making it an important chemical in the development of cancer treatments with novel mechanisms of action. Further research and clinical trials are needed to fully understand its therapeutic potential.

Upstream product

• 70138-72-6 (R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 35150-07-3 (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate 
• 117175-41-4 tert‐butyl (S)‐2‐carbamothioylpyrrolidine‐1‐carboxylate 
• 212009-06-8 ethyl (S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate 

Downstream Products

• 1005342-78-8 C₁₉H₂₁FN₂O₃S 
• 1005342-82-4 C₃₁H₄₁FN₄O₅S 
• 1005342-46-0 (2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide 

Relevant articles and documents

HMG-COA REDUCTASE DEGRADATION INDUCING COMPOUND

The present invention relates HMG-CoA reductase degradation inducing compounds. Specifically, the present invention relates a bifunctional compound in which a HMG-CoA reductase binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention also relates a method for preparing the compounds, and a method for degradation of HMG-CoA reducatase using the compounds, as well as use for prevention or treatment of HMG-CoA reductase related diseases using the compounds.

MDM2 DEGRADERS AND USES THEREOF

The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.

BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY

The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.