251365-22-7

Basic information

• Product Name: (3S,4R)-[(1S)-1-(3,4,5-tribenzyloxyphenyl)-1-hydroxymethyl]-4-(3,4-methylenedioxybenzyl)dihydro-2(3H)-furanone
• CAS NO: 251365-22-7
• Molecular Weight: 644.721
• Mol File: 251365-22-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,4R)-[(1S)-1-(3,4,5-tribenzyloxyphenyl)-1-hydroxymethyl]-4-(3,4-methylenedioxybenzyl)dihydro-2(3H)-furanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-[(1S)-1-(3,4,5-tribenzyloxyphenyl)-1-hydroxymethyl]-4-(3,4-methylenedioxybenzyl)dihydro-2(3H)-furanone(251365-22-7)
• EPA Substance Registry System: (3S,4R)-[(1S)-1-(3,4,5-tribenzyloxyphenyl)-1-hydroxymethyl]-4-(3,4-methylenedioxybenzyl)dihydro-2(3H)-furanone(251365-22-7)

Safety Data

• Hazardous Substances Data: 251365-22-7(Hazardous Substances Data)

Upstream product

• 6137-86-6 3,4,5-tribenzyloxybenzaldehyde 
• 17187-77-8 (R)-(+)-3-piperonyl-4-butanolide 
• 100-39-0 benzyl bromide 
• 70424-94-1 methyl 3,4,5-tris(benzyloxy)benzoate 
• 79831-88-2 3,4,5-tribenzyloxybenzyl alcohol 
• 99-24-1 methyl galloate 

Relevant articles and documents

Stereoselective syntheses of (-)-podorhizol lignan and its derivatives: Erythro and threo preferential aldol condensation of potassium enolate from γ-butyrolactone with alkoxybenzaldehyde

(-)-Podorhizol (1) was stereoselectively synthesized by erythro preferential aldol condensation of 3,4,5-trimethoxybenzaldehyde with potassium enolate from (+)-(R)-3-(3,4-methylenedioxybenzyl)-4-butanolide (2) (erythro: threo=85:15). Erythro selectivity was observed in the aldol condensation of many alkoxybenzaldehydes with potassium enolate from (+)-γ-butyrolactone 2. However, benzaldehydes having methoxy groups at both the 2 and 6 positions gave threo selectivity in the aldol condensation with potassium enolate from (+)-γ-butyrolactone 2.