2514-18-3

Basic information

• Product Name: 4-chloro-5-methoxy-2-phenylpyridazin-3(2H)-one
• Synonyms: 4-chloro-5-methoxy-2-phenyl-2,3-dihydropyridazin-3-one; 4-Chloro-5-methoxy-2-phenyl-2,3-dihydropyridazinone
• CAS NO: 2514-18-3
• Molecular Formula: C₁₁H₉ClN₂O₂
• Molecular Weight: 236.6544
• Mol File: 2514-18-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 366.8°C at 760 mmHg
• Flash Point: 175.6°C
• Density: 1.31g/cm³
• Vapor Pressure: 1.43E-05mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 4-chloro-5-methoxy-2-phenylpyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-5-methoxy-2-phenylpyridazin-3(2H)-one(2514-18-3)
• EPA Substance Registry System: 4-chloro-5-methoxy-2-phenylpyridazin-3(2H)-one(2514-18-3)

Safety Data

• Hazardous Substances Data: 2514-18-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1698-53-9 4,5-dichloro-1-phenylpyridazin-6-one 

Downstream Products

• 93562-63-1 2,5-dihydro-3-chloro-4-methoxy-5-phenyliminopyrrol-2-one 

Relevant articles and documents

Prostaglandin endoperoxide H synthase biosynthesis inhibitors

The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).