25143-11-7Relevant articles and documents
Synthesis and in vitro cytotoxic evaluation of 7-chloro-4-anilino-quinoline amide derivatives
Trung Hieu, Bui,Thuy, Vu Thu,Tien, Hoang Xuan,Vu, Tran Khac
, p. 4453 - 4456 (2013/06/27)
A series of new amide derivatives of 4-anilino-quinoline have been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1) and human breast cancer (MCF-7). Compound 5g was found to be most potent cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 2.09 and 4.63 μg/mL, respectively. Compound 5e exhibited significant cytotoxic activity against three cell lines with IC50 values ranging from 5-10 μg/mL.