25152-96-9

Upstream product

• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 

Downstream Products

• 141928-25-8 C₅₂H₅₄N₇O₁₄PS 
• 1034146-24-1 C₃₆H₄₁N₇O₁₃ 
• 80875-87-2 C₁₀H₁₂N₅O₁₁P₃S^(4-) 
• 118275-89-1 C₂₀H₂₀N₅O₁₃P₃S^(2-) 
• 141928-26-9 5'-O-(N⁶-benzoyl-3'-O-(diisopropylaminomethoxyphosphino)-2'-deoxyadenosyl) 3'-O-<5'-O-(dimethoxytrityl)thymidine> O-methyl phosphorothioate 
• 224298-18-4 5'-O-(N⁶-benzoyl-2'-deoxyadenosyl) 3'-O-<5'-O-(dimethoxytrityl)thymidine> O-β-cyanoethyl phosphorothioate 
• 141955-64-8 5'-O-(N⁶-benzoyl-2'-deoxyadenosyl) 3'-O-<5'-O-(dimethoxytrityl)thymidine> O-methyl phosphorothioate 
• 130767-64-5 Thiophosphoric acid O-[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester O'-[(2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester 

Relevant academic research and scientific papers

Synthesis of formacetal-linked dinucleotides to facilitate dsDNA bending and binding to the homeodomain of Pax6

Two formacetal-linked dinucleotides T∧T and T∧A were synthesized as phosphoramidite building blocks for solid-phase synthesis. Incorporated in a 29-mer DNA, the oligomers P3T∧T and P3T∧A were studied with respect to the binding activ

An alternative route to the preparation of (3' → 5') methylene acetal linked di- and trinucleosides

Reaction of deoxynucleoside 3'-O-(methylthiomethyl) acetals 1 with N-iodosuccinimide (NlS) and dibutyl phosphate furnished the corresponding 3'-O-(dibutoxyphosphoryloxy)methyl acetals 6. Condensation of the latter with appropriately protected deoxynucleoside acceptors 3, in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf), afforded in most cases the (3' → 5') methylene acetal linked d(B(1Λ) B2) dimers 4. In addition, TMSOTf-promoted coupling of donor 6 (B1 = C(Bz)) with 3'-O-(methylthiomethyl)thymidine (8) yielded dimer 9. Reaction of 9 with NIS and dibutyl phosphate gave dimer 10, which was applied successfully in the TMSOTf-assisted fusion with acceptors 3 (B2 = C(Bz) and A(Bz)), to afford the corresponding trimers d(C(Λ)T(Λ)C) 11 and d(C(Λ)T(Λ)A) 12.