25153-08-6

Basic information

• Product Name: (2R)-2-(naphthalen-2-yloxy)propanoic acid
• Synonyms: (2R)-2-(2-Naphthyloxy)propanoic acid; propanoic acid, 2-(2-naphthalenyloxy)-, (2R)-
• CAS NO: 25153-08-6
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.2326
• Mol File: 25153-08-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 389.7°C at 760 mmHg
• Flash Point: 152.1°C
• Density: 1.231g/cm³
• Vapor Pressure: 9.05E-07mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: (2R)-2-(naphthalen-2-yloxy)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-(naphthalen-2-yloxy)propanoic acid(25153-08-6)
• EPA Substance Registry System: (2R)-2-(naphthalen-2-yloxy)propanoic acid(25153-08-6)

Safety Data

• Hazardous Substances Data: 25153-08-6(Hazardous Substances Data)

Upstream product

• 10470-82-3 2-(2-naphthalenyloxy)propanoic acid 
• 62784-66-1 bis(1-naphthyl)methanol 
• 30406-75-8 2-(naphthalen-2-yloxy)-propionic acid methyl ester 
• 32644-15-8 (S)-2-bromopropanoic acid 
• 135-19-3 β-naphthol 

Relevant articles and documents

A new method for production of chiral 2-aryloxypropanoic acids using effective kinetic resolution of racemic 2-aryloxycarboxylic acids

We report a novel method for the preparation of 2-aryloxypropanoic acids by kinetic resolution of racemic 2-aryloxypropanoic acids using enantioselective esterification. The usage of pivalic anhydride (Piv2O) as an activating agent, bis(a-naphthyl)methanol ((α-Np)2CHOH) as an achiral alcohol, and (+)-benzotetramisole ((+)-BTM) as a chiral acyl-transfer catalyst enables the effective separation of various racemic 2-aryloxypropanoic acids to afford optically active carboxylic acids and the corresponding esters with high enantioselectivities. Furthermore, theoretical calculations of the transition states required to form the chiral esters successfully proved the enantiomer recognition mechanism of the asymmetric esterification.