251539-10-3

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 251539-00-1 3-cyano-4-(4-chlorophenyl)-5,6-dihydrothieno[2,3-h]quinolin-2(1H)-thione 
• 251538-99-5 5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one 
• 251539-04-5 2-[4-(4-chloro-phenyl)-3-cyano-5,6-dihydro-thieno[2,3-h]quinolin-2-ylsulfanyl]-acetamide 

Downstream Products

• 251539-16-9 12-(4-chlorophenyl)-10,11-dihydropyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinolin-4(3H)-one 
• 251539-21-6 14-(4-chlorophenyl)-12,13-dihydro-[1,2,4]triazolo[4'',3'':1',6']pyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinolin-4(5H)-thione 
• 251539-18-1 12-(4-chlorophenyl)-4-hydrazino-10,11-dihydropyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinoline 
• 251539-17-0 4-chloro-12-(4-chlorophenyl)-10,11-dihydropyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinoline 

Relevant academic research and scientific papers

A convenient synthesis of dithieno[2,3-b] [2,3-h]quinolines and pyrimido [4′,5′:4,5]thieno [2,3-b]thieno[2,3-h]quinolines

6,7-Dihydrobenz[b]thiophen-4(5H)one (1) was condensed with 4- chlorobenzaldehyde to yield the benzylidene derivative 2 which underwent Michael addition reacting with cyanothioacetamide in methanolic sodium methoxide solution to give the thienoquinoline 3. Compound 3 was reacted with α- halo compounds to obtain the substituted thio intermediates 4a-f, which upon treatment with sodium ethoxide produce the dithienoquinoline derivatives 5a-f. Thienopyrimidothienoquinoline e.g. 9 was obtained from the reaction of ?- aminocarboxamide derivative 5d with triethyl orthoformate.