251547-34-9Relevant academic research and scientific papers
Synthesis of targetable cationic amphiphiles
Ren, Tan,Dexi, Liu
, p. 7621 - 7625 (2007/10/03)
Cationic amphiphiles 1a-1c, with monosaccharide at the ω-position of the hydrocarbon tails, were synthesized by utilization of Schmidt's trichloroacetimidate procedure for the glycosylation step and application of the commercially available 3,5-dihydroxybenzyl alcohol as a scaffold for the attachment of double hydrocarbon tails. Application of the Zemplen condition for O-deacetylation in the presence of base-sensitive benzyl bromide was found to be efficient. The synthetic route provides an entry for the synthesis of versatile quaternary ammonium amphiphiles having the cell targeting glycosyl ligands.
