25181-65-1

Basic information

• Product Name: 2-(2-bromo-3-methylphenoxy)acetic acid
• Synonyms: 2-(2-bromo-3-methylphenoxy)acetic acid
• CAS NO: 25181-65-1
• Molecular Weight: 245.073
• Mol File: 25181-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-bromo-3-methylphenoxy)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromo-3-methylphenoxy)acetic acid(25181-65-1)
• EPA Substance Registry System: 2-(2-bromo-3-methylphenoxy)acetic acid(25181-65-1)

Safety Data

• Hazardous Substances Data: 25181-65-1(Hazardous Substances Data)

Upstream product

• 38197-43-2 2-bromo-3-methylanisole 
• 50868-73-0 2-methoxy-6-methylbenzeneamine 
• 22061-78-5 2-bromo-3-methylphenol 
• 79-11-8 chloroacetic acid 

Relevant articles and documents

1,2-asymmetric induction in diastereoselective zwitterionic aza-Claisen rearrangements: Key steps in optically active alkaloid synthesis

The zwitterionic aza-Claisen rearrangement of optically active N-allylpyrrolidines and α-phenoxyacetyl fluorides proceeds with complete simple diastereoselectivity (internal asymmetric induction) and complete 1,2-asymmetric induction to generate a new C-C bond adjacent to a chiral C-N-Boc functionality. The resulting γ,δ-unsaturated amides were cyclised to give the corresponding pyrrolizidinones, which enabled the determination of the relative configuration of the stereotriads. Vinyl group degradation and a final lactam reduction gave an optically active analogue of (+)-petasinine (a pyrrolizidine alkaloid). Furthermore, the stereotriad-containing amides should be useful key intermediates for the total synthesis of optically active elaeocarpin (an indolizidine alkaloid). Copyright