25185-93-7

Upstream product

• 22439-61-8 2-bromodibenzothiophene 
• 132-65-0 dibenzothiophene 
• 22099-23-6 dibenzo[b, d]thiophene-2-carbaldehyde 

Downstream Products

• 113525-36-3 2-S-phenylthiomethyldibenzothiophene 

Relevant academic research and scientific papers

Synthesis of triphenylphosphonium dibenzothiophene S-oxide derivatives and their effect on cell cycle as photodeoxygenation-based cytotoxic agents

Photodeoxygenation of Dibenzothiophene-S-oxide (DBTO) in UV-A light produces atomic oxygen [O(3P)] and the corresponding sulfide, dibenzothiophene (DBT). Recently, DBTO has been derivatized to study the effect of UV-A light-driven photodeoxygenation in lipids, proteins, and nucleic acids. In this study, two DBTO derivatives with triphenylphosphonium groups were synthesized to promote mitochondrial accumulation. The sulfone analogs of these derivatives were also synthesized and used as fluorescent mitochondrial dyes to assess localization in mitochondria of HeLa cells. These derivatives were then used to study the effect of photodeoxygenation on MDA-MB-231 breast cancer cell line using cell viability assays, cell cycle phase determination tests, and RNA-Seq analysis. The DBTO derivatives were found to significantly decrease cell viability only after UV-A irradiation as a result of generating corresponding sulfides that were found to significantly affect gene expression and cell cycle.

PHOTOSWITCHABLE DIBENZOTHIENYLMETHYL TRIPHENYLPHOSPHONIUM DERIVATIVES AND METHODS OF TREATING CANCER THEREWITH

In one aspect, the present disclosure provides a compound of the formula: In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.

Synthesis, experimental and theoretical characterization, and field-effect transistor properties of a new class of dibenzothiophene derivatives: From linear to cyclic architectures

We report the synthesis and characterization of a bis-dibenzothiophene cyclic dimer containing bis-ethylene linkages (DBT-CM) and of the corresponding mono-ethylene-linked 'linear' cis- and trans-isomers (cis- and trans-DBT-LM, respectively). The varied molecular architectures lead to notable differences both in terms of the solid-state packing and the molecular electronic and optical properties. X-ray crystallography reveals that the cyclic architecture of DBT-CM leads to a more densely packed stacking configuration that imparts stronger intermolecular electronic coupling for both hole and electron transport amongst adjacent molecules, while characterization of the thin-film morphology and crystallinity uncovers important temperature-dependent properties of the films as a function of the molecular architecture. Moreover, the redox, electronic structure, and optical properties of DBT-CM vary distinctly from those of its linear counterparts. The intramolecular reorganization energies for hole and electron transport for DBT-CM are markedly smaller than the linear counterparts, while the dispersion for the highest valence band (and the intermolecular electronic coupling for hole transport) is the largest for the series. The more favorable molecular packing/morphology characteristics and charge-transport properties (within the Marcus framework) of DBT-CM manifest themselves in thin-film field-effect transistor studies, where a field-effect hole-carrier mobility 0.026 cm2 V-1 s-1 is measured, a value one-order-of-magnitude larger than either linear analog. The Royal Society of Chemistry 2012.

Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation

The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: pharmaceuticals containing them and their use for the treatment of malignant and other diseases based on pathological cell proliferation.

Synthesis of Multisulfur-Containing Substituted Dibenzothiophenes

New substituted dibenzothiophenes have been prepared and characterized.Selective functionalizations utilized substitutions of lithiodibenzothiophenes available from established methodology.New dibenzothiophenes prepared include 2-(bromomethyl)dibenzothiop