251983-54-7Relevant academic research and scientific papers
The chemical synthesis and cytotoxicity of new sulfur analogues of 2-methoxy-lysophosphatidylcholine
Rytczak, Przemyslaw,Drzazga, Anna,Gendaszewska-Darmach, Edyta,Okruszek, Andrzej
, p. 6794 - 6798 (2014/01/06)
The chemical synthesis of phosphorothioate/phosphorodithioate analogues of 2-methoxy-lysophosphatidylcholine has been described. For the preparation of new sulfur derivatives of lysophosphatidylcholine both oxathiaphospholane and dithiaphospholane approaches have been employed. Each lysophospholipid analogue was synthesized as a series of five compounds, bearing different fatty acid residues both saturated (12:0, 14:0, 16:0, 18:0) and unsaturated (18:1). The methylation of glycerol 2-hydroxyl function was applied in order to increase the stability of prepared analogues by preventing 1→2 acyl migration. The cellular toxicity of newly synthesized 2-methoxy-lysophosphatidylcholine derivatives was measured using MTT viability assay and lactate dehydrogenase release method.
Kinetics and pathways for an algal phospholipid (1,2-dioleoyl-sn-glycero-3- phosphocholine) in high-temperature (175-350 °c) water
Changi, Shujauddin,Savage, Phillip E.,Matzger, Adam J.
, p. 2856 - 2867,12 (2020/09/14)
We examined the behavior of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in high-temperature water at 175, 200, 225, and 350 °C. DOPC hydrolyzed to give oleic acid and a number of phosphorus-containing products. The hydrolysis was catalyzed by oleic and phosphoric acids, which were also reaction products. DOPC formed 1-acyl and 2-acyl lyso-phosphatidylcholine (LPC) along with oleic acid as primary products. LPC subsequently formed other phosphorus-containing intermediates, which finally led to phosphoric acid as the ultimate P-containing product. At 350 °C, phosphoric acid and oleic acid were the only products observed. We observed an ester of oleic acid and glycerol (9-octadecenoic-2,3- dihydroxypropyl ester), which likely formed via the hydrolysis of LPC. A reaction network is proposed to explain the formation of the observed products. A quantitative kinetics model based on the proposed pathways was consistent with the experimental data.
Enzymatic synthesis of monoglycerides by esterification reaction using Penicillium camembertii lipase immobilized on epoxy SiO2-PVA composite
Freitas, Larissa,Paula, Ariela V.,dos Santos, Julio C.,Zanin, Gisella M.,de Castro, Heizir F.
experimental part, p. 87 - 90 (2010/10/19)
Glycerol-fatty acid esterification has been conducted with lipase from Penicillium camembertii lipase immobilized on epoxy SiO2-PVA in solvent-free media, with the major product being 1-monoglyceride, a useful food emulsifier. For a given set of initial conditions, the influence of reaction was measured in terms of product formation and selectivity using different fatty acids as acyl donors. Results were found to be relatively dependent of the chain length of the fatty acids, showing high specificity for both myristic and palmytic acids attaining final mixture that fulfills the requirements established by the World Health Organization to be used as food emulsifiers.
A new catalyst for the preparation of oleate of glycerin
Rongsheng, Li,Hua, Yang,Wuyang, Zhang,Quan, Wei,Naixiang, Wei
, p. 449 - 451 (2007/10/02)
In this investigation sulfate promoted titanium oxide (SPTO) is used to prepare oleate of glycerin, an excellent internal lubricant for manufacturing transparent sheet materials of polyvinylchloride (PVC).Experimental results show that the occasional saponification caused by the conventional sodalye catalyst for preparing oleate of glycerin can be avoided completely.SPTO can be used repeatedly without any special treatment.Its activity is comparable with that of sodalye.Also the use of SPTO can produce the desirable product composition.SPTO is likely to become a new catalyst for the production of oleate of glycerin.
