251983-85-4Relevant academic research and scientific papers
Enzymatic desymmetrization of meso cis-2,6- and cis,cis-2,4,6-substituted piperidines. Chemoenzymatic synthesis of (5S,9S)-(+)-indolizidine 209D
Chenevert, Robert,Ziarani, Ghodsi Mohammadi,Morin, Marie Pascale,Dasser, Mohammed
, p. 3117 - 3122 (1999)
The stereoselective acylation of meso piperidines 3a,b by vinyl acetate (solvent and acyl donor) in the presence of Candida antarctica lipase gave the corresponding (2S,6R) and (2S,4R,6R) monoesters 2a,b in high enantiomeric purity. (5S,9S)-(+)-Indolizidine 209D was prepared in eight steps from (2S,6R)-2a.
A chemoenzymatic-RCM strategy for the enantioselective synthesis of new dihydroxylated 5-hydroxymethyl-indolizidines and 6-hydroxymethyl-quinolizidines
Lesma, Giordano,Colombo, Alessia,Landoni, Nicola,Sacchetti, Alessandro,Silvani, Alessandra
, p. 1948 - 1954 (2007)
A direct method for the synthesis of new azasugars-like compounds has been developed, which involves a new biocatalytic protocol based on the use of a lipase from Candida Cylindracea and of a ionic liquid as reaction medium, to prepare the key C1/su
