251996-86-8 Usage
Uses
Used in Pharmaceutical Industry:
4-trifluoromethyl-2-hydroxy-pyrimidine-5-carboxylic acid is used as a key intermediate in the synthesis of Sant-75 analogs, which are Hedgehog-pathway inhibitors. These inhibitors play a crucial role in the development of targeted therapies for various cancers, as the Hedgehog signaling pathway is often dysregulated in tumor cells, contributing to uncontrolled cell growth and proliferation.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-trifluoromethyl-2-hydroxy-pyrimidine-5-carboxylic acid serves as a valuable starting material for the design and development of novel therapeutic agents. Its unique structural features allow for the creation of diverse chemical libraries, which can be screened for potential biological activities, such as anti-inflammatory, antiviral, or antibacterial properties.
Used in Drug Delivery Systems:
Similar to gallotannin, 4-trifluoromethyl-2-hydroxy-pyrimidine-5-carboxylic acid can also be incorporated into drug delivery systems to enhance its bioavailability and therapeutic efficacy. By employing various carriers, such as organic and metallic nanoparticles, the compound can be effectively delivered to target cells, improving its overall performance in treating specific medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 251996-86-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,1,9,9 and 6 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 251996-86:
(8*2)+(7*5)+(6*1)+(5*9)+(4*9)+(3*6)+(2*8)+(1*6)=178
178 % 10 = 8
So 251996-86-8 is a valid CAS Registry Number.
251996-86-8Relevant academic research and scientific papers
THIADIAZOLE MODULATORS OF PKB
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Page/Page column 130; 131, (2009/03/07)
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the th
A facile and general synthesis of 2,4-di- and 2,4,7-trisubstituted thieno[2,3-c]pyridines
Zhu, Gui-Dong,Gunawardana, Indrani W.,Boyd, Steven A.,Melcher, Laura M.
, p. 91 - 96 (2008/09/19)
(Chemical Equation Presented) Treatment of 3,5-dibromo- or 3,5-dichloro-pyridine-4-carboxaldehyde 2 with one equivalent of methyl thioglycolate, followed by exposure to base, provided 4-bromo- or 4-chloro-thieno[2,3-c]pyridine-2-carboxylate 4 in good yiel
Cell adhesion-inhibiting antiinflammatory compounds
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, (2008/06/13)
Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
