251996-85-7Relevant academic research and scientific papers
THIADIAZOLE MODULATORS OF PKB
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Page/Page column 130-131, (2009/03/07)
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the th
A facile and general synthesis of 2,4-di- and 2,4,7-trisubstituted thieno[2,3-c]pyridines
Zhu, Gui-Dong,Gunawardana, Indrani W.,Boyd, Steven A.,Melcher, Laura M.
, p. 91 - 96 (2008/09/19)
(Chemical Equation Presented) Treatment of 3,5-dibromo- or 3,5-dichloro-pyridine-4-carboxaldehyde 2 with one equivalent of methyl thioglycolate, followed by exposure to base, provided 4-bromo- or 4-chloro-thieno[2,3-c]pyridine-2-carboxylate 4 in good yiel
Cell adhesion-inhibiting antiinflammatory compounds
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, (2008/06/13)
Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression
Stewart,Bhatia,McCarty,Patel,Staeger,Arendsen,Gunawardana,Melcher,Zhu,Boyd,Fry,Cool,Kiflie,Lartey,Marsh,Kempf-Grote,Kilgannon,Wisdom,Meyer,Gallatin,Okasinskit
, p. 988 - 1002 (2007/10/03)
A critical early event in the inflammatory cascade is the induced expression of cell adhesion molecules on the lumenal surface of vascular endothelial cells. These adhesion molecules include E-selectin, ICAM-1, and VCAM-1, which serve to recruit circulati
