252001-23-3Relevant academic research and scientific papers
Synthesis of complex nucleoside antibiotics
Ichikawa, Satoshi,Matsuda
, p. 319 - 329 (2007/10/03)
Herbicidin B and fully protected tunicaminyluracil, which were undecose nucleoside antibiotics, were synthesized using a samarium diiodide (SmI 2) mediated aldol reaction with the use of α-phenylthioketone as an enolate. The characteristics of
The first synthesis of herbicidin B. stereoselective construction of the tricyclic undecose moiety by a conformational restriction strategy using steric repulsion between adjacent bulky silyl protecting groups on a pyranose ring
Ichikawa, Satoshi,Shuto, Satoshi,Matsuda, Akira
, p. 10270 - 10280 (2007/10/03)
The first total synthesis of the nucleoside antibiotic herbicidin B (1b) was achieved, where a novel aldol-type C-glycosidation reaction promoted by samarium diiodide (SmI2) was used as a key step. Treatment of methyl 3,4-O-(1,1,3,3-tetraisopro
