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4-(2-fluorophenyl)piperidine-4-carbonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 252002-43-0 Structure
  • Basic information

    1. Product Name: 4-(2-fluorophenyl)piperidine-4-carbonitrile
    2. Synonyms: 4-(2-fluorophenyl)piperidine-4-carbonitrile
    3. CAS NO:252002-43-0
    4. Molecular Formula: C12H13FN2
    5. Molecular Weight: 204.2434232
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 252002-43-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(2-fluorophenyl)piperidine-4-carbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(2-fluorophenyl)piperidine-4-carbonitrile(252002-43-0)
    11. EPA Substance Registry System: 4-(2-fluorophenyl)piperidine-4-carbonitrile(252002-43-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 252002-43-0(Hazardous Substances Data)

252002-43-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 252002-43-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,2,0,0 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 252002-43:
(8*2)+(7*5)+(6*2)+(5*0)+(4*0)+(3*2)+(2*4)+(1*3)=80
80 % 10 = 0
So 252002-43-0 is a valid CAS Registry Number.

252002-43-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2-fluorophenyl)piperidine-4-carbonitrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:252002-43-0 SDS

252002-43-0Relevant articles and documents

A convenient synthesis of 1′-H-spiro-(indoline-3,4′-piperidine) and its derivatives

Xie, Jian-Shu,Huang, Charles Q.,Fang, Yan-Yan,Zhu, Yun-Fei

, p. 4875 - 4878 (2007/10/03)

A simple synthetic route has been developed to prepare 1′-H- spiro(indoline-3,4′-piperidine) (1d). Dialkylation of 2- fluorophenylacetonitrile with N-(tert-butyloxycarbonyl)-bis(2-chloroethyl)amine (5) gave 6. Deprotection of Boc followed by cyclization resulted 1d in 67% overall yield. Selective Boc or Cbz protection of 1′-N gave 1a or 1b with 90 and 85% yield, respectively. Thus, in a five-step procedure, 1a and 1b were synthesized from commercially available reagents in over 50% overall yield. All 3 compounds (1a, 1b and 1d) can be utilized as templates to synthesize compounds for GPCR targets.

Design and synthesis of novel α(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

Dhar, T. G. Murali,Nagarathnam, Dhanapalan,Marzabadi, Mohammad R.,Lagu, Bharat,Wong, Wai C.,Chiu, George,Tyagarajan, Sriram,Miao, Shou Wu,Zhang, Fengqi,Sun, Wanying,Tian, Dake,Shen, Quanrong,Zhang, Jack,Wetzel, John M.,Forray, Carlos,Chang, Raymond S. L.,Broten, Theodore P.,Schorn, Terry W.,Chen, Tsing Bao,O'Malley, Stacy,Ransom, Richard,Schneck, Kathryn,Bendesky, Robert,Harrell, Charles M.,Vyas, Kamlesh P.,Zhang, Kanyin,Gilbert, John,Pettibone, Douglas J.,Patane, Michael A.,Bock, Mark G.,Freidinger, Roger M.,Gluchowski, Charles

, p. 4778 - 4793 (2007/10/03)

We have previously described compound 1a as a high-affinity subtype selective α(1a) antagonist. In vitro and in vivo evaluation of compound 1a showed its major metabolite to be a μ-opioid agonist, 4-methoxycarbonyl-4- phenylpiperidine (3). Several dihydropyrimidinone analogues were synthesized with the goal of either minimizing the formation of 3 by modification of the linker or finding alternative piperidine moieties which when cleaved as a consequence of metabolism would not give rise to μ-opioid activity. Modification of the linker gave several compounds with good {1a) binding affinity (K(i) = 300 fold over α(1b) and α(1d)). In vitro analysis in the microsomal assay revealed these modifications did not significantly affect N-dealkylation and the formation of the piperidine 3. The second approach, however, yielded several piperidine replacements for 3, which did not show significant μ-opioid activity. Several of these compounds maintained good affinity at the α(1a) adrenoceptor and selectivity over α(1b) and α(1d). For example, the piperidine fragments of (+)-73 and (+)-83, viz. 4-cyano-4-phenylpiperidine and 4-methyl-4-phenylpiperidine, were essentially inactive at the μ-opioid receptor (IC50 > 30 μM vs 3 μM for 3). Compounds (+)-73 and (+)-83 were subjected to detailed in vitro and in vivo characterization. Both these compounds, in addition to their excellent selectivity (> 880-fold) over α(1b) and α(1d), also showed good selectivity over several other recombinant human G-protein coupled receptors. Compounds (+)-73 and (+)-83 showed good functional potency in isolated human prostate tissues, with K(b)s comparable to their in vitro α(1a) binding data. In addition, compound (+)-73 also exhibited good uroselectivity (DBP K(b)/IUP K(b) > 20-fold) in the in vivo experiments in dogs, similar to 1a.

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