171-75-5

Basic information

• Product Name: SPIRO[INDOLINE-3,4'-PIPERIDINE]
• Synonyms: 1,2-DIHYDRO-1'H-SPIRO[INDOLE-3,4'-PIPERIDINE];SPIRO[INDOLINE-3,4'-PIPERIDINE];1,2-Dihydrospiro[3H-indole-3,4'-piperidine];1,2-dihydrospiro[indole-3,4'-piperidine];Spiro[3H-indole-3,4'-piperidine], 1,2-dihydro-;1,2-Dihydrospiro[3H-indole-3,4'-piperidine] 2HCl
• CAS NO: 171-75-5
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.272
• Mol File: 171-75-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 140-142℃
• Appearance: /
• Density: 1.13
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SPIRO[INDOLINE-3,4'-PIPERIDINE](CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[INDOLINE-3,4'-PIPERIDINE](171-75-5)
• EPA Substance Registry System: SPIRO[INDOLINE-3,4'-PIPERIDINE](171-75-5)

Safety Data

• Hazardous Substances Data: 171-75-5(Hazardous Substances Data)

Usage

Uses

Spiro[indoline-3,4''-piperidine], can be used for the synthesis of the spiro-indanone derivatives, acting as an antagonists of the human CCR5 receptor as anti-HIV-1 agents.

Upstream product

• 326-62-5 2-fluorophenyl acetonitrile 
• 55-86-7 mechlorethamine hydrochloride 
• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 
• 100-63-0 phenylhydrazine 
• 167484-18-6 benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 726198-18-1 4-cyano-4-(2-fluorophenyl)-1-N-(tert-butyloxycarbonyl)piperidine 
• 252002-43-0 4-cyano-4-(2-fluorophenyl)piperidine 

Downstream Products

• 167484-18-6 benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 870072-74-5 1,2-dihydro-1-(2-nitrophenyl)-spiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid phenylmethyl ester 
• 870072-22-3 1-(2-(spiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea 
• 870072-29-0 1-(2-(1'-benzylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea 
• 1093955-94-2 (1S)-1-{1-[(2E)-3-(3,5-difluorophenyl)-2-propenoyl]-4-piperidinyl}-2-(1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)ethanol 
• 958007-08-4 tert-butyl [2-({[6-(1,2-dihydro-1'H-spiro[indole-3.4'-piperidin]-1'-yl)pyridine-3-yl]carbonyl}amino)-4-(2-thienyl)phenyl]carbamate 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC DERIVATIVES AS GPR AGONISTS AND USES THEREOF

The present invention generally relates to substituted heterocyclic derivatives (the compounds of Formula (I)), processes for their preparation, pharmaceutical compositions containing said compounds, their use as G-protein coupled receptor (GPR) agonists, particularly as GPR40 agonists and methods of using these compounds in the treatment of GPR40 mediated diseases or conditions such as Type 2 diabetes, obesity, dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

SPIROINDOLINES AS MODULATORS OF CHEMOKINE RECEPTORS

The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases

N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions

The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.