25206-11-5

Upstream product

• 3465-72-3 urocanic Acid 
• 76-83-5 trityl chloride 
• 1030268-24-6 trimethylsulphoxonium iodide 
• 25274-94-6 sec-butyl (2E)-3-(1-trityl-1H-imidazol-4-yl)acrylate 
• 25274-93-5 sec-butyl (2E)-3-(1H-imidazol-4-yl)acrylate 

Downstream Products

• 408348-69-6 (1S,2S)-2-formyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane 
• 250672-66-3 (1R,2R)-2-formyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane 
• 223419-90-7 4-((1S,2S)-2-(5,5-dimethyl-hex-1-yn-1-yl)-cyclopropyl)-1-trityl-1H-imidazole 
• 223419-88-3 4-((1R,2R)-2-(5,5-dimethyl-hex-1-yn-1-yl)-cyclopropyl)-1-trityl-1H-imidazole 
• 223419-93-0 (1S,2S)-4-(2-ethynylcyclopropyl)-1-(triphenylmethyl)imidazole 
• 223419-91-8 (1R,2R)-4-(2-ethynylcyclopropyl)-1-(triphenylmethyl)imidazole 
• 201669-69-4 ((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(1S,2S)-2-(1-trityl-1H-imidazol-4-yl)-cyclopropyl]-methanone 
• 201669-70-7 ((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(1R,2R)-2-(1-trityl-1H-imidazol-4-yl)-cyclopropyl]-methanone 

Relevant academic research and scientific papers

An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

GT-2331 is a potent histamine H3 antagonist which has entered clinical trials. Efficient multigram syntheses of this compound and its enantiomer are described. The literature reports that GT-2331 is the dextrorotatory (+), more potent, enantiom