25220-24-0Relevant academic research and scientific papers
An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions
Tsai, Yi-Ling,Fan, Yu-Shiou,Lee, Chia-Jui,Huang, Chan-Hui,Das, Utpal,Lin, Wenwei
supporting information, p. 10266 - 10268 (2013/10/22)
Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.
