252235-49-7

Upstream product

• 22627-70-9 3-ethoxycyclopent-2-en-1-one 
• 192181-83-2 3-(3'-hydroxypropyl)-2-cyclopenten-1-one 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 345221-63-8 Toluene-4-sulfonic acid 3-(3-hydroxy-cyclopent-1-enyl)-propyl ester 
• 345207-58-1 Acetic acid 3-(3-benzylamino-propyl)-cyclopent-2-enyl ester 
• 78877-19-7 1-benzyl-1-azaspiro[4.4]non-6-ene 
• 252235-51-1 acetic acid 2-bromo-3-[3-(toluene-4-sulfonyloxy)-propyl]-cyclopent-2-enyl ester 
• 252235-48-6 acetic acid 3-[3-(toluene-4-sulfonyloxy)-propyl]-cyclopent-2-enyl ester 
• 252235-56-6 acetic acid 3-[3-(toluene-4-sulfonyloxy)-propyl]-cyclopent-2-enyl ester 
• 252235-50-0 4-toluenesulfonic acid 3-(2-bromo-3-oxo-cyclopent-1-enyl)-propyl ester 

Relevant academic research and scientific papers

Intramolecular 1,3-dipolar cycloaddition as a tool for the preparation of azaspirocyclic keto aziridines. Synthesis of intermediates for the total synthesis of (±) (±)-cephalotaxine

The thermal intramolecular azide-enone 1,3-dipolar cycloaddition to azaspirocyclic keto aziridines 17 and 18 is reported. α-Hydroxylation and oxidation to the corresponding diketo aziridine 2 provided an intermediate in a synthetic approach toward cephalo

Palladium-catalyzed synthesis of cephalotaxine analogues

The synthesis of cephalotaxine ring analogues 10 was achieved by two successive intramolecular palladium-catalyzed reactions of 12 via 11, namely an allylic amination and a Heck reaction. The substrates 12 were obtained by alkylation of primary amines 13 with tosylates 14.

PALLADIUM ASSISTED SYNTHESIS OF 1-AZASPIROCYCLES

A facile, general route to 1-azaspirocycles utilizing a ?-allyl palladium complex in the key cyclization step has been developed.