252327-39-2Relevant academic research and scientific papers
Design and synthesis of novel α(1a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series
Wong, Wai C.,Sun, Wanying,Lagu, Bharat,Tian, Dake,Marzabadi, Mohammad R.,Zhang, Fengqi,Nagarathnam, Dhanapalan,Miao, Shou W.,Wetzel, John M.,Peng, Jian,Forray, Carlos,Chang, Raymond S. L.,Chen, Tsing B.,Ransom, Richard,O'Malley, Stacey,Broten, Theodore P.,Kling, Paul,Vyas, Kamlesh P.,Zhang, Kanyin,Gluchowski, Charles
, p. 4804 - 4813 (1999)
We have previously disclosed dihydropyridines such as 1a,b as selective α(1a) antagonists as a potential treatment for benign prostatic hyperplasia (BPH). The propensity of dihydropyridines toward an oxidation led us to find suitable replacements of the core unit. The accompanying papers describe the structure-activity relationship (SAR) of dihydropyrimidinones 2a,b as selective α(1a) antagonists. We report herein the SAR of dihydropyrimidines such as 4 and highlight the similarities and differences between the dihydropyrimidine and dihydropyrimidinone series of compounds.
