25233-49-2

Usage

Chemical Properties

Bright yellow crystalline powder

InChI:InChI=1/C10H10N2O4/c1-7(13)5-10(14)11-8-3-2-4-9(6-8)12(15)16/h2-4,6H,5H2,1H3,(H,11,14)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 99-09-2 3-nitro-aniline 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 51903-70-9 Acetoacet-m-nitranilid-2,3-dioxim 
• 94461-01-5 (2-Hydroxy-5-sulfamoyl-phenylazo)-3-nitro-acetoacetanilid 
• 112697-73-1 2-Methyl-[1,8]naphthyridine-3-carboxylic acid (3-nitro-phenyl)-amide 
• 130088-00-5 [3-Methyl-5-(3-nitro-phenylamino)-pyrazol-1-yl]-pyridin-4-yl-methanone 
• 83999-15-9 C₁₆H₁₂N₅O₁₀^(1-)*C₆H₁₅N*H⁽¹⁺⁾ 
• 674-82-8 4-methyleneoxetan-2-one 
• 99-09-2 3-nitro-aniline 
• 130087-94-4 (2-Hydroxy-phenyl)-[3-methyl-5-(3-nitro-phenylamino)-pyrazol-1-yl]-methanone 
• 1282423-47-5 C₂₇H₂₁ClN₆O₃S 
• 1282423-27-1 C₂₇H₂₁ClN₆O₄ 
• 1374747-50-8 3-acetyl-5-(2-hydroxybenzoyl)-1-(3-nitrophenyl)-1H-pyridin-2-one 
• 1448691-78-8 4-hydroxy-4-methyl-2-(3-nitrophenyl)-2-azaspiro[4.4]nonan-1-one 
• 1448692-11-2 C₁₄H₁₆N₂O₄ 
• 1607003-03-1 3-acetyl-1-(3-nitrophenyl)-1H-chromeno[4,3-b]pyridine-2,5-dione 

Relevant academic research and scientific papers

Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives

Abstract: A series of N-substituted-6-methyl-4-{4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxyphenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides have been synthesized by the condensation of newly synthesized {4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol. The synthesized compounds have been characterized by 1H, 13C NMR, IR spectroscopy, and mass spectrometry. All synthesized compounds were evaluated for in vitro antidiabetic activity using the α-amylase inhibition assay with the 3,5-dinitrosalicylic acid (DNSA) reagent.

Phenothiazine and amide-ornamented novel nitrogen heterocyclic hybrids: synthesis, biological and molecular docking studies

The synthesis of novel hybrids, namely, phenothiazine and amide-ornamented nitrogen heterocycles (25-34) has been accomplished utilizing a multi-step synthetic protocol and the structures have been established based on physical and spectral techniques. Of these, the hybrids possessing meta-nitro (26), para-fluoro (28), meta- and para-methyl (31), ortho-bromo (33) and ortho- and para-dimethyl (34) phenyl carboxamide scaffolds exhibited superior anti-inflammatory profiles over the standard diclofenac sodium. A hybrid integrated with a para-fluorophenyl carboxamide moiety (28) showed the highest DPPH radical scavenging activity among the chemical entities synthesized. Furthermore, the results of anticancer evaluations implied that the hybrid tethered with a phenyl carboxamide structural unit (29) exerted superior activity when compared with other hybrids against the pancreatic cancer cells SW1990 and AsPC1. Molecular docking between the hybrid 29 and B-cell lymphoma 2 reflects its appreciable binding affinity (-8.84 kcal mol-1). The results revealed that these chemical entities can serve as potent biological agents and/or efficient intermediates for the construction of potent biological agents.

Phenothiazine and amide-ornamented dihydropyridines: Via a molecular hybridization approach: Design, synthesis, biological evaluation and molecular docking studies

A series of novel phenothiazinyldihydropyridine dicarboxamides 7a-7j was synthesized by adopting a multi-step synthetic strategy and characterized through physical and spectral techniques. Among them, the chemical entities with para-fluoro (7d), ortho-bromo and-fluoro (7f and 7i), ortho- A nd para-methyl (7e) and meta- A nd para-methoxy (7h) substituents exhibited either similar or superior anti-inflammatory activities with respect to the standard drug diclofenac sodium. Besides, the chemical entities with ortho-bromo and-fluoro substituents as well as meta-nitro substituents (7f, 7g and 7i) showed enhanced radical scavenging activities when compared to standard ascorbic acid. Furthermore, anticancer studies revealed that the meta- A nd para-chloro-substituted molecule 7a exerted the best activity against all the pancreatic cancer cells tested. Also, appreciable binding affinity (-8.10 kcal mol-1) was observed during molecular docking between B-cell lymphoma 2 and 7a. The structural diversifications of the potent chemical entities besides further exploration in connection with the biological profiles of the same are underway.

Effective microwave synthesis of bioactive thieno[2,3-d]pyrimidines

A series of novel 2-Amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K2CO3) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno[2,3-d]pyrimidines (3a-3j) and thieno[2,3-d]pyrimidin-2(1H)-ones(4a-4j) respectively. The reaction rates were faster and yields were higher in the microwave conditions. The structures of the compounds were confirmed with elemental analysis, mass spectral analysis, FTIR, 1H NMR and 13C NMR techniques. All the synthesized compounds were subjected to antimicrobial activity (MIC) in vitro by broth dilution method and exhibited a moderate antimicrobial activity.

COMPOUND HAVING AZO SKELETON, PIGMENT DISPERSANT, PIGMENT COMPOSITION, PIGMENT DISPERSION, AND TONER

A compound that improves the dispersibility of pigments in non-water-soluble solvents is provided. A pigment dispersant, a pigment composition, a pigment dispersion, and a toner in which this compound is used are also provided. This compound has a polymer

COMPOUND HAVING AZO SKELETON STRUCTURE, PIGMENT-DISPERSING AGENT, PIGMENT COMPOSITION, PIGMENT DISPERSION, AND TONER

The present invention provides a compound capable of improving the dispersibility of color pigments in a water-insoluble solvent; and a pigment-dispersing agent. The present invention also provides a pigment composition, a pigment dispersion, and a toner,

Design, Multicomponent Synthesis and Characterization of Diversely Substituted Pyrazolo[1,5-a] Pyrimidine Derivatives

The synthesis of various heterocyclic compounds using acetoacetanilide[AAA], we have demonstrated that acetoactanilide are versatile intermediate for the synthesis of pyrazolopyrimidine derivatives. Thus, to explore further, we sought that the reaction of various acetoactanilide, an appropriate aldehyde and 5-amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide in the presence of base in isopropyl alcohol could be an effective strategy to furnish the novel pyrazolopyrimidine derivatives. Here we describe the novel synthetic methodology for the fused pyrazolopyrimidines.

METHOD FOR PRODUCING COMPOUND HAVING COLORANT STRUCTURE AT MAIN CHAIN TERMINAL OF POLYMER, AND PIGMENT DISPERSANT, PIGMENT COMPOSITION, PIGMENT DISPERSION AND TONER CONTAINING COMPOUND OBTAINED BY THE PRODUCTION METHOD

To provide a method for producing a compound that enhances dispersibility of a pigment of respective colors in a water-insoluble solvent, as well as a pigment dispersant, and a pigment composition, a pigment dispersion and a toner having a good tinting po

METHOD OF PRODUCING A COMPOUND HAVING A COLORANT STRUCTURE, AND TONER CONTAINING A COMPOUND OBTAINED BY THE PRODUCTION METHOD

Provided are a method of producing a compound having a colorant structure suitable for a pigment dispersant, and a pigment dispersant, a pigment composition, a pigment dispersion, and a toner each containing the compound. The production method is a method

COMPOUND HAVING AZO SKELETON STRUCTURE, PIGMENT DISPERSING AGENT, PIGMENT COMPOSITION, PIGMENT DISPERSION, AND TONER

PROBLEM TO BE SOLVED: To provide a compound that improves dispersibility of color pigments in a non-water-soluble solvent and a pigment dispersing agent, and also provide a pigment composition, a pigment dispersion, and a toner which have satisfactory tin