252338-34-4Relevant academic research and scientific papers
Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram
Barnes, David M.,Wittenberger, Steven J.,Zhang, Ji,Ji, Jianguo,Fickes, Michael G.,Fitzgerald, Michael A.,King, Steven A.,Morton, Howard E.,Plagge, Frederick A.,Preskill, Margo,Wagaw, Seble H.
, p. 13097 - 13105 (2002)
The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished via the discovery and development of a highly selective catalytic asymmetric conjugate addition of ketoesters to nitroolefins. Employing just 4 mol % bis(oxazoline)-Mg
