252340-90-2

Upstream product

• 5728-07-4 3-hydroxy-1,2,5-thiadiazole 
• 195816-25-2 (5R)-3-(4-(1-Benzyl-1,2,5,6-tetrahydropyridin-4-yl)-3-fluorophenyl)-5-hydroxymethyl-oxazolidin-2-one 

Downstream Products

• 783291-36-1 (R)-3-[3-Fluoro-4-(1,2,3,6-tetrahydro-pyridin-4-yl)-phenyl]-5-([1,2,5]thiadiazol-3-yloxymethyl)-oxazolidin-2-one 
• 252342-23-7 acetic acid 2-(4-{2-fluoro-4-[2-oxo-5-([1,2,5]thiadiazol-3-yloxymethyl)-oxazolidin-3-yl]-phenyl}-3,6-dihydro-2H-pyridin-1-yl)-2-oxo-ethyl ester 

Relevant academic research and scientific papers

New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains

Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563.