25238-54-4Relevant academic research and scientific papers
Copper-catalyzed C-N cross-coupling reactions for the preparation of aryl diamines applying mild conditions
Costa, Márcio V.,Viana, Gil M.,De Souza, Thaís M.,Malta, Luiz Fernando B.,Aguiar, Lúcia C.S.
, p. 2332 - 2335 (2013/06/27)
In this work, aryl diamines were prepared by C-N cross-coupling reactions between aryl halides and ethylenediamine. These reactions were successfully catalyzed by low quantities of Cu2O or CuO (1 mol %) employing low reflux temperature and low diamine excess. Products were afforded in good yields (up to 95%).
Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells
Cuenca, Francisco,Moore, Michael J.B.,Johnson, Karin,Guyen, Berangere,De Cian, Anne,Neidle, Stephen
supporting information; experimental part, p. 5109 - 5113 (2010/03/31)
A series of 4,5-di-substituted acridones have been designed and synthesized. Several compounds show high affinity for telomeric G-quadruplex DNA in classical and competition FRET assays, together with low duplex DNA affinity, although they do not show activity in a telomerase assay or evidence of telomere shortening. They have low toxicity against a panel of cancer cell lines and a normal human fibroblast line, and produce potent senescence-based long-term growth arrest in the MCF7 and A549 cancer cell lines.
1-Aryl-3-alkyl-1,4,5,6-tetrahydropyrimidinium salts. Part 2. Reactions with nucleophiles
Garcia, Maria B.,Zani, Mariana,Perillo, Isabel A.,Orelli, Liliana R.
, p. 2557 - 2572 (2007/10/03)
The reactivity of 1-aryl-3-alkyl-1,4,5,6-tetrahydropyrimidinium salts (1) towards nucleophiles was studied. Hydrolysis of salts (1) afforded initially compounds (2, kinetic products) through the corresponding amidinium hydroxides (4). The regioselectivity
