25245-35-6Relevant articles and documents
Heck- And Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase
Kempton, Robert J.,Kidd-Kautz, Taylor A.,Laurenceau, Soizic,Paula, Stefan
supporting information, p. 971 - 975 (2019/06/08)
In this study, we explored Heck- and Suzuki-coupling methodology to modify the template 2,5-di-tert-butylhydroquinone (BHQ, 2), an inhibitor of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA). We found that by utilizing Suzuki coupling, we c
One-pot ortho-amination of aryl C-H bonds using consecutive iron and copper catalysis
Henry, Martyn C.,McGrory, Rochelle,Faggyas, Réka J.,Mostafa, Mohamed A. B.,Sutherland, Andrew
, p. 4629 - 4639 (2019/05/17)
A one-pot approach for ortho-coupling of arenes with non-actived N-nucleophiles has been developed using sequential iron and copper catalysis. Regioselective ortho-activation of anisoles, anilines and phenols was achieved through iron(iii) triflimide catalysed iodination, followed by a copper(i)-catalysed, ligand-assisted coupling reaction with N-heterocycle, amide and sulfonamide-based nucleophiles. The synthetic utility of this one-pot, two-step method for the direct amination of ortho-aryl C-H bonds was demonstrated with the late-stage functionalisation of 3,4-dihydroquinolin-2-ones. This allowed the preparation of a TRIM24 bromodomain inhibitor and a series of novel analogues.
Rapid aerobic iodination of arenes mediated by hypervalent iodine in fluorinated solvents
Iskra, Jernej,Murphree, S. Shaun
supporting information, p. 645 - 648 (2017/01/28)
Arenes are rapidly converted to the corresponding iodides by aerobic oxidative iodination at room temperature by treatment with iodine and catalytic quantities of nitrous acid in a fluorinated solvent. Dichloroiodic acid is proposed as the actual iodination reagent.
