252562-00-8Relevant academic research and scientific papers
Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors
Pan, Chenghao,Nie, Wenwen,Wang, Jiao,Du, Jiamin,Pan, Zhichao,Gao, Jian,Lu, Yang,Che, Jinxin,Zhu, Hong,Dai, Haibin,Chen, Binhui,He, Qiaojun,Dong, Xiaowu
, (2021/09/06)
Aberrant activation of the fibroblast growth factor 19-fibroblast growth factor receptor 4 (FGF19-FGFR4) signaling pathway has been proved to promote hepatocellular carcinoma (HCC) proliferation. It is assumed that the first FGFR4 inhibitor BLU9931 did no
Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration
Lunniss, Christopher J.,Cooper, Anthony W.J.,Eldred, Colin D.,Kranz, Michael,Lindvall, Mika,Lucas, Fiona S.,Neu, Margarete,Preston, Alex G.S.,Ranshaw, Lisa E.,Redgrave, Alison J.,Ed Robinson,Shipley, Tracy J.,Solanke, Yemisi E.,Somers, Don O.,Wiseman, Joanne O.
scheme or table, p. 1380 - 1385 (2009/10/02)
Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokine
