252574-02-0Relevant articles and documents
NON-FUSED TRICYCLIC COMPOUNDS
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Paragraph 00695, (2018/11/26)
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.
Synthesis of diversely functionalised 2,2-disubstituted oxetanes: Fragment motifs in new chemical space
Davis, Owen A.,Croft, Rosemary A.,Bull, James A.
supporting information, p. 15446 - 15449 (2015/10/20)
Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via rhodium-catalysed O-H insertion and C-C bond forming cyclisation.
COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT
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Paragraph 0614-0616, (2013/10/22)
Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections