215922-85-3

Usage

Uses

Used in Organic Synthesis:
Trans-1-Boc-3-cyano-4-hydroxypyrrolidine is used as a building block for the synthesis of various organic compounds due to its unique structure and reactivity. It serves as a key intermediate in the production of complex organic molecules, facilitating the creation of a wide range of chemical entities.
Used in Medicinal Chemistry:
In the pharmaceutical industry, trans-1-Boc-3-cyano-4-hydroxypyrrolidine is utilized as a crucial component in the development of new drugs. Its presence in the molecular structure can impart specific biological activities, making it an essential tool for medicinal chemists in the design and synthesis of potential therapeutic agents.
Used in Agrochemicals:
Trans-1-Boc-3-cyano-4-hydroxypyrrolidine also finds application in the agrochemical sector, where it is employed in the synthesis of various agrochemical products. Its versatility allows for the development of compounds with specific pesticidal or herbicidal properties, contributing to the advancement of agricultural solutions.
Used in Fine Chemicals:
trans-1-Boc-3-cyano-4-hydroxypyrrolidine is also used in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors. Its role in this context is to provide a stable and versatile intermediate for the synthesis of high-quality specialty chemicals.
Overall, trans-1-Boc-3-cyano-4-hydroxypyrrolidine's applications span across multiple industries, highlighting its importance as a chemical intermediate and its contribution to the development of innovative products in research and commercial settings.

Upstream product

• 175463-32-8 3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 266353-18-8 N-tert-butoxycarbonyl-2-(2-cyanoethyl)aminoacetic acid ethyl ester 
• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 108-05-4 vinyl acetate 
• 197143-33-2 tert-butyl 3-cyano-4-hydroxypyrrolidine-1-carboxylate 
• 913744-14-6 (S,S)-3-acetoxy-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 7677-24-9 trimethylsilyl cyanide 
• 114214-49-2 rac-tert-butyl (1R,5S)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 5804-85-3 diethylaluminium cyanide 
• 252574-02-0 (±)-trans-tert-butyl 3-bromo-4-hydroxypyrrolidine-1-carboxylate 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 44981-94-4 N-cyanoethyl glycine ethyl ester 

Downstream Products

• 773826-73-6 tert-butyl 3-(aminomethyl)-4-hydroxypyrrolidine-1-carboxylate 
• 895241-95-9 (3S,4S)-3-cyano-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 895241-94-8 (R,R)-3-hydroxy-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 913744-14-6 (S,S)-3-acetoxy-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Preparation and application of imidazo aromatic ring compounds

The invention provides preparation and application of imidazo aromatic ring compounds, and particularly provides compounds as shown in the following formula I. The definition of each group is as shownin the specification. The compounds have TRK kinase inh

ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF

A compound of Formula (I) or or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating hearing loss or balance disorder: Formula (I) wherein R1 and Y are as defined herein.

PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES

The present invention relates to pyrazolo [1,5 -a] [1,3,5 ]triazine and pyrazolo[1,5-a] pyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazo lo [1,5-a][1,3,5 ]triazine and pyrazolo [1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF

Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.

Pyrazolo[1,5-A]pyrimidines as antiviral agents

The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT

Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections

PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS

The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

CHIRAL AUXILIARIES

Chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity, and compounds represented by the following the general formula (I) or the general formula (XI) for introducing the chiral auxiliaries.

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

Cyclic amines

The invention is concerned with cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1′, R1″ and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments and for treating diseases associated with coagulation factor Xa.