252574-53-1Relevant academic research and scientific papers
Stereospecific Pd(O)-Catalyzed Malonate Additions to Allylic Hydroxy Phosphonate Derivatives: A Formal Synthesis of (-)-Enterolactone
Yan, Bingli,Spilling, Christopher D.
, p. 2859 - 2862 (2004)
A combination of cross-metathesis and malonate addition was applied to a formal synthesis of the mammalian lignan enterolactone 5. The cross-metathesis of alkene 6 and phosphonate 3a gave the substituted allylic phosphonate 3d. The palladium-catalyzed add
Allylic hydroxy phosphonates: Versatile chiral building blocks
De La Cruz, Antonette,He, Anyu,Thanavaro, Anchalee,Yan, Bingli,Spilling, Christopher D.,Rath, Nigam P.
, p. 2577 - 2592 (2007/10/03)
Allylic hydroxy phosphonates are converted into β and γ substituted amino phosphonates using a series of palladium-catalyzed reactions. The judicious selection of nitrogen nucleophile and palladium catalyst allow for excellent regio- and stereochemical co
