25261-51-2Relevant academic research and scientific papers
Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors
Oza, Vibha B.,Petrassi, H. Michael,Purkey, Hans E.,Kelly, Jeffery W.
, p. 1 - 6 (2007/10/03)
Eight small molecules were synthesized to evaluate the structure activity relationships (SAR) of N-substituted anthranilic acids. The molecules were synthesized by benzylation or arylation of methyl anthranilate. A light scattering-based amyloid fibril formation assay was used to evaluate potential inhibitors of transthyretin (TTR) amyloid fibril formation in vitro. The m-carboxyphenylated and o-trifluoromethylphenylated anthranilic acids are potent inhibitors that will be subjected to further SAR and structural analysis.
