2527-61-9Relevant academic research and scientific papers
Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus
Ngo, Huy X.,Shrestha, Sanjib K.,Green, Keith D.,Garneau-Tsodikova, Sylvie
, p. S1 - S53 (2016/12/07)
Antibiotic resistance is a worldwide problem that needs to be addressed. Staphylococcus aureus is one of the dangerous “ESKAPE” pathogens that rapidly evolve and evade many current FDA-approved antibiotics. Thus, there is an urgent need for new anti-MRSA compounds. Ebselen (also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one) has shown promising activity in clinical trials for cerebral ischemia, bipolar disorder, and noise-induced hearing loss. Recently, there has been a renewed interest in exploring the antibacterial properties of ebselen. In this study, we synthesized an ebselen-inspired library of 33 compounds where the selenium atom has been replaced by sulfur (ebsulfur derivatives) and evaluated them against a panel of drug-sensitive and drug-resistant S. aureus and non-S. aureus strains. Within our library, we identified three outstanding analogues with potent activity against all S. aureus strains tested (MIC values mostly ?2?μg/mL), and numerous additional ones with overall very good to good antibacterial activity (1–7.8?μg/mL). We also characterized the time-kill analysis, anti-biofilm ability, hemolytic activity, mammalian cytotoxicity, membrane-disruption ability, and reactive oxygen species (ROS) production of some of these analogues.
Antithrombotic agent
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, (2008/06/13)
Certain 2,2'-dithiobis-N-substituted or unsubstituted benzamides or derivatives thereof are useful as antithrombotic agents because of their ability to suppress aggregation of blood platelets.
STUDIES ON ORGANOPHOSPHORUS COMPOUNDS. THIATION OF 3,1-BENZOXATHIAN-4-ONES. NEW ROUTES TO 1,2-BENZISOTHIAZOLE-3(2H)-THIONES AND 3H-1,2-BENZODITHIOL-3-IMINES
El-Barbary, A. A.,Clausen, K.,Lawesson, S.-O.
, p. 3309 - 3316 (2007/10/02)
3,1-Benzoxathian-4-ones, 2, when heated with 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide, 1, or with P4S10 give one or more of the following products: 3,1-benzoxathian-4-thione, 3, 1,3-benzodithian-4-one, 4, 1,3-benzodithian-4-thion
