2528-00-9

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE is used as a starting material for the synthesis of 5-hydroxymethylfuran-2-carboxylic acid, which is essential in the development of new pharmaceutical compounds.
Used in the Synthesis of Antagonists:
In the field of protein-protein interaction research, ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE is used as a starting material for the synthesis of novel sulfamideand urea-based small-molecule antagonists of the protein-protein interaction IL-2/IL-2Rα. These antagonists have potential applications in the treatment of various diseases and conditions related to the immune system.
Used in Chemical Research and Development:
As a clear yellow liquid with unique chemical properties, ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE is also used in various chemical research and development projects, where it can be further modified or combined with other compounds to create new materials or products with specific applications in different industries.

InChI:InChI=1/C8H9ClO3/c1-2-11-8(10)7-4-3-6(5-9)12-7/h3-4H,2,5H2,1H3

Upstream product

• 614-99-3 Ethyl 2-furoate 
• 76448-73-2 ethyl 5-(hydroxymethyl)furan-2-carboxylate 
• 1623-88-7 5-chloromethylfurfural 
• 105850-77-9 5-(chloromethyl)-2-furancarbonyl chloride 
• 64-17-5 ethanol 
• 6338-41-6 5-hydroxymethyl-furan-2-carboxylic acid 
• 50-00-0 formaldehyd 

Downstream Products

• 101094-15-9 5-benzoyloximethyl-furan-2-carboxylic acid ethyl ester 
• 99187-01-6 ethyl 5-(acetoxymethyl)-2-furoate 
• 91903-26-3 5-(benzylmercapto-methyl)-furan-2-carboxylic acid 
• 51129-66-9 5-cyanomethyl-furan-2-carboxylic acid ethyl ester 
• 76448-73-2 ethyl 5-(hydroxymethyl)furan-2-carboxylate 
• 446054-20-2 5-[N-(2-methyl-3-furoyl)amino]methylfuran-2-carboxylic acid 
• 51521-95-0 5-aminomethyl-2-furancarboxylic acid hydrochloride salt 
• 94084-70-5 5-(methylsulfanyl-methyl)-furan-2-carboxylic acid 
• 106166-79-4 5-(ethylmercapto-methyl)-furan-2-carboxylic acid 
• 102439-45-2 5-(propylmercapto-methyl)-furan-2-carboxylic acid 
• 100397-64-6 5-(toluene-α-sulfonylmethyl)-furan-2-carboxylic acid 
• 1225910-83-7 1-[5-(chloromethyl)fur-2-yl]-2-(2,4-difluorophenyl)ethanone 
• 1379508-09-4 N-((5-((phenylaminoethyl)carbamoyl)furan-2-yl)methyl)pterin-7-carboxamide 
• 1379508-22-1 C₁₄H₁₅N₅O₂ 

Relevant academic research and scientific papers

Diversification of the Renewable Furanic Platform via 5-(Chloromethyl)furfural-Based Carbon Nucleophiles

Biobased 5-(chloromethyl)furoate and 5-methylfuroate esters can be deprotonated to function as furylogous lithium enolates, and the former can also undergo zinc insertion to access Reformatsky-type chemistry. Carbon nucleophilicity represents hitherto lit

PREPARATION OF ACID CHLORIDES FROM 5-(CHLOROMETHYL) FURFURAL

Acid chloride derivatives of 5-(chloromethyl)furan-2-carboxylic acid and furan-2,5-dicarboxylic acid (FDCA) can be produced in high yield by treatment of the precursor aldehydes 5-(chloromethyl)furfural (CMF) and 2,5-diformylfuran (DFF) with tert-butyl hypochlorite, which is inexpensively prepared from commercial bleach and tert-butanol. 5-(Chloromethyl)furan-2-carbonyl chloride (CMFCC) and furan-2,5-dicarbonyl chloride (FDCC) are highly useful intermediates for the production of furoate ester biofuels and polymers of FDCA.

Production of 5-(chloromethyl)furan-2-carbonyl chloride and furan-2,5-dicarbonyl chloride from biomass-derived 5-(chloromethyl)furfural (CMF)

Acid chloride derivatives of 5-(chloromethyl)furan-2-carboxylic acid and furan-2,5-dicarboxylic acid (FDCA) can be produced in high yield by treatment of the precursor aldehydes 5-(chloromethyl) furfural (CMF) and 2,5-diformylfuran (DFF) with tert-butyl hypochlorite, which is inexpensively prepared from commercial bleach and tert-butanol. 5-(Chloromethyl)furan-2-carbonyl chloride (CMFCC) and furan-2,5-dicarbonyl chloride (FDCC) are highly useful intermediates for the production of furoate ester biofuels and polymers of FDCA.

A new synthesis of 8-oxabicyclo[3.2.1]octan-2-one and its use for the preparation of cycloheptane annulated furans

Two novel syntheses of 8-oxabicyclo[3.2.1]octan-2-one are described, making this key intermediate readily available in preparative amounts. On chain elongation with various oxophosphonates this compound is converted to α,β-unsaturated ketones, which, on t

NOVELIMIDAZOLECARBOXAMIDE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

The invention relates to the compounds of the general formula (I), in which A, D, R, R1 and X are as defined in the description, to a process for the preparation thereof and to the therapeutic use thereof in the treatment of pathologies associa

PROSTANOIDS. HYBRID 7-THIA-16-ARYLOXY-9,11-DIDEOXY-10-KETOPROSTANOIDS

The 7-thia-16-aryloxy-9,11-dideoxy-10-keto analogs of prostaglandin E1 were obtained by the conjugate 1,4-addition of 6-mercaptohexanoic and 5-mercaptomethylfuran-2-carboxylic esters to 4-(3-hydroxy-4-phenoxy-1E-butenyl)-2-cyclopenten-1-one.It was established that the addition takes place with the preferential formation of the isomers with the trans arrangement of the side chains.