25283-73-2

Basic information

• Product Name: 1,2,5-Thiadiazole, 3-methyl-4-phenyl-
• CAS NO: 25283-73-2
• Molecular Formula: C9H8N2S
• Molecular Weight: 176.242
• Mol File: 25283-73-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,2,5-Thiadiazole, 3-methyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Thiadiazole, 3-methyl-4-phenyl-(25283-73-2)
• EPA Substance Registry System: 1,2,5-Thiadiazole, 3-methyl-4-phenyl-(25283-73-2)

Safety Data

• Hazardous Substances Data: 25283-73-2(Hazardous Substances Data)

Upstream product

• 4057-62-9 3-phenyl-1,2,5-thiadiazole 
• 917-64-6 methyl magnesium iodide 
• 5728-06-3 3-methyl-1,2,5-thiadiazole 
• 13213-36-0 1-phenylpropan-2-one oxime 
• 2157-50-8 propiophenone oxime 
• 103-79-7 1-phenyl-acetone 

Downstream Products

• 576-54-5 trans-benzene hexabromide 
• 75204-42-1 4H-<1>benzopyrano<3,4-c><1,2,5>thiadiazole-4-one 
• 93517-53-4 cis-1,2-Dibromo-1,2-bis(4-phenyl-1,2,5-thiadiazol-3-yl)ethylene 
• 93517-54-5 trans-1,2-Dibromo-1,2-bis(4-phenyl-1,2,5-thiadiazol-3-yl)ethylene 
• 93517-52-3 3-Dibromomethyl-4-phenyl-1,2,5-thiadiazole 
• 93517-51-2 3-Bromomethyl-4-phenyl-1,2,5-thiadiazole 

Relevant articles and documents

Reactions of alkyl methyl ketoximes with tetrasulfur tetranitride antimony pentachloride complex (S4N42.SbCl5): A regioselective formation of 3-alkyl-4-methyl-1,2,5-thiadiazoles and their mechanism of formation

Treatment of alkyl methyl ketoximes with tetrasulfur tetranitride antimony pentachloride complex (S4N4·SbCl5) in aromatic solvents such as benzene and toluene at 60 °C led to the regioselective formation of 3-alkyl- 4-methyl-1,2,5-thiadiazoles in low yields, whereas the reactions of alkyl aryl ketoximes under the same conditions gave exclusively N-arylalkanamides in good yields. A mechanism is proposed for the formation of 3-alkyl-4- methyl-1,2,5-thiadiazoles.

A-ALKYLATION, ALKENYLATION, AND ARYLATION OF 1,2,5-THIADIAZOLES

A new synthetic method of 1,2,5-thiadiazoles is reported, which affording mono- or disubstituted derivatives by one pot procedure, clarifies unknown aspects of the 1,2,5-thiadiazole ring reactivity.