25283-73-2

Upstream product

• 4057-62-9 3-phenyl-1,2,5-thiadiazole 
• 917-64-6 methyl magnesium iodide 
• 2157-50-8 propiophenone oxime 
• 5728-06-3 3-methyl-1,2,5-thiadiazole 
• 13213-36-0 1-phenylpropan-2-one oxime 
• 103-79-7 1-phenyl-acetone 

Downstream Products

• 576-54-5 trans-benzene hexabromide 
• 75204-42-1 4H-<1>benzopyrano<3,4-c><1,2,5>thiadiazole-4-one 
• 93517-53-4 cis-1,2-Dibromo-1,2-bis(4-phenyl-1,2,5-thiadiazol-3-yl)ethylene 
• 93517-54-5 trans-1,2-Dibromo-1,2-bis(4-phenyl-1,2,5-thiadiazol-3-yl)ethylene 
• 93517-52-3 3-Dibromomethyl-4-phenyl-1,2,5-thiadiazole 
• 93517-51-2 3-Bromomethyl-4-phenyl-1,2,5-thiadiazole 

Relevant academic research and scientific papers

Reactions of alkyl methyl ketoximes with tetrasulfur tetranitride antimony pentachloride complex (S4N42.SbCl5): A regioselective formation of 3-alkyl-4-methyl-1,2,5-thiadiazoles and their mechanism of formation

Treatment of alkyl methyl ketoximes with tetrasulfur tetranitride antimony pentachloride complex (S4N4·SbCl5) in aromatic solvents such as benzene and toluene at 60 °C led to the regioselective formation of 3-alkyl- 4-methyl-1,2,5-thiadiazoles in low yields, whereas the reactions of alkyl aryl ketoximes under the same conditions gave exclusively N-arylalkanamides in good yields. A mechanism is proposed for the formation of 3-alkyl-4- methyl-1,2,5-thiadiazoles.

Reactions of Tetrasulfur Tetranitride with Alkyl Aryl Ketoximes: Synthesis of 3-Aryl- and 3-Alkyl-4-aryl-1,2,5-thiadiazoles

Tetrasulfur tetranitride (S4N4) was treated with various alkyl aryl ketoximes having two hydrogens at the α-carbon atom to the oxime functionality in p-dioxane at reflux to give 3-substituted and 3,4-disubstituted 1,2,5-thiadiazoles in moderate yields.Rea

A-ALKYLATION, ALKENYLATION, AND ARYLATION OF 1,2,5-THIADIAZOLES

A new synthetic method of 1,2,5-thiadiazoles is reported, which affording mono- or disubstituted derivatives by one pot procedure, clarifies unknown aspects of the 1,2,5-thiadiazole ring reactivity.