252865-95-5Relevant academic research and scientific papers
Metal complexation and DNA cleavage activities of N-substituted hydroxamic acids
Ghosh, Kallol K.,Tamrakar, Pankaj,Jadhav, Vasant R.
, p. 712 - 715 (2007/10/03)
Hydroxamic acid, RCON(R')OH, is a bidentate oxygen ligand possessing affinity for a variety of metal ions. The Cu(II) complexes of three N- substituted hydroxamic acids [R=C6H5; R'=C6H5, 4-CH3 - C6H4 and R'= C6H5.CH2] have been synthesized and characterized. Their DNA cleavage activities have been investigated using plasmid DNA. An oxidative mechanism for DNA cleavage by hydroxy radicals via abstraction of a H atom from sugar unit has been proposed.
